Results 231 to 240 of about 38,957 (260)

A Novel Peptide Inhibits Induction of Nitric Oxide Synthase

1996
Alpha-melanocyte stimulating hormone has been shown to prevent endotoxin shock. A heptapeptide analog (HPA) has recently been synthesized and shown to be an even more potent protective agent. Since the hypotensive and toxic actions of endotoxin lipopolysaccharide (LPS) appear to involve the induction of nitric oxide synthase, we have examined the ...
G. Abou-Mohamed, A. Papapetropoulos, R. W. Caldwell   +2 more
openaire   +1 more source

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

Natural Product Reports, 2018
The protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrids are summarized and discussed.
Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi   +2 more
openaire   +2 more sources

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond–forming enzymes

Nature Chemical Biology, 2009
Cyclodipeptides and their derivatives belong to the diketopiperazine (DKP) family, which is comprised of a broad array of natural products that exhibit useful biological properties. In the few known DKP biosynthetic pathways, nonribosomal peptide synthetases (NRPSs) are involved in the synthesis of cyclodipeptides that constitute the DKP scaffold ...
Gondry, Muriel, Sauguet, Ludovic, Belin, Pascal, Thai, Robert, Amouroux, Rachel, Tellier, Carine, Tuphile, Karine, Jacquet, Mickaël, Braud, Sandrine, Courçon, Marie, Masson, Cédric, Dubois, Steven, Lautru, Sylvie, Lecoq, Alain, Hashimoto, Shin-Ichi, Genet, Roger, Pernodet, Jean-Luc   +16 more
openaire   +4 more sources

Inhibition of nitric oxide synthase with calmodulin binding peptides

2005
The constitutive isoforms of nitric oxide synthase (nNOS and eNOS) are regulated by calmodulin, which adopts an active conformation upon binding calcium and binds to target proteins. The inducible isoform of NOS (iNOS) copurifies with calmodulin [1] and was reported not to require calcium for activation [2].
Karen S. Gregson, Michael A. Marletta, Henry I. Mosberg   +2 more
openaire   +1 more source

A connection between antimicrobial properties of venom peptides and microbial ATP synthase

International Journal of Biological Macromolecules, 2018
Venom peptides anoplin, cupiennin 1a, latarcin 1, latarcin 3a, latarcin 5, melittin, and pandinin 2 are known to have antibacterial properties. In the current study, we examined whether the antimicrobial properties of these venom peptides have any connection to the binding and inhibition of bacterial ATP synthase.
Hiba Syed, Mohammad Tauseef, Zulfiqar Ahmad   +2 more
openaire   +2 more sources

Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Enzymes of Fungi

2018
Fungi are known to produce various nonribosomal peptide-derived compounds that exhibit useful bioactivities. However, understanding of how those fungal secondary metabolites are biosynthesized still remains limited. In this review, we focus on recent efforts in engineering select fungal species to make them amenable to efficient genetic modifications ...
Shinji Kishimoto, Yuichiro Hirayama, Kenji Watanabe   +2 more
openaire   +1 more source

THYMIDYLATE SYNTHASE RELATED POLYEPITOPE PEPTIDE CANCER THERAPEUTICS

2005
VACCINO PEPTIDICO ANTITIMIDILATO SINTASI PER LA TERAPIA DI NEOPLASIE MALIGNE PRODUCENTI ...
P. CORREALE, CUSI, MARIA GRAZIA, G. GIORGI, FRANCINI, GUIDO   +3 more
openaire   +1 more source

The ATP Synthase ofTrypanosoma bruceiIs Developmentally Regulated by an Inhibitor Peptide

Archives of Biochemistry and Biophysics, 1996
The Trypanosoma brucei ATP synthase, like those of other organisms, is composed of two moieties, the membrane bound F0 and the catalytic F1 with each of these parts comprised of multiple subunits. In addition, an endogenous inhibitor peptide of the ATP synthase has been identified from a variety of sources.
T B, Chi, S Y, Choi, N, Williams
openaire   +2 more sources

Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

Natural Product Reports, 2007
A total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). We report on the distribution of these systems in different bacterial taxa and, whenever known, the metabolites they synthesize.
Stefano, Donadio, Paolo, Monciardini, Margherita, Sosio   +2 more
openaire   +2 more sources

Assembly of aryl‐capped siderophores by modular peptide synthetases and polyketide synthases

Molecular Microbiology, 2000
Bacterial siderophores assist pathogens in iron acquisition inside their hosts. They are often essential for achieving a successful infection, and their biosynthesis represents an attractive antibiotic target. Recently, several siderophore biosynthetic loci have been identified, and in vitro studies have advanced our knowledge of the biosynthesis of ...
openaire   +2 more sources