Results 31 to 40 of about 38,957 (260)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

ATP Synthase: A Molecular Therapeutic Drug Target for Antimicrobial and Antitumor Peptides [PDF]

Current Medicinal Chemistry, 2013
In this review we discuss the role of ATP synthase as a molecular drug target for natural and synthetic antimicrobial/ antitumor peptides. We start with an introduction of the universal nature of the ATP synthase enzyme and its role as a biological nanomotor.
Ahmad, Zulfiqar, Okafor, Florence, Azim, Sofiya, Laughlin, Thomas F.   +3 more
openaire   +3 more sources

The sORF-Encoded Peptides, ATP Synthase Subunits, Facilitate WSSV Duplication in Shrimp

Viruses, 2022
Short open reading frames (sORFs) are a newly identified family of genes, and the functions of most sORF genes and their encoded peptides (SEPs) are still unknown. In this study, two ATP synthase subunits were identified in kuruma shrimp (Marsupenaeus japonicus) as SEPs, namely MjATP5I and MjATP5L.
Li-Jie Huo, Peng-Yuan Lu, Dian-Xiang Li, Xiu-Zhen Shi   +3 more
openaire   +3 more sources

Inhibition of the ATP synthase sensitizes Staphylococcus aureus towards human antimicrobial peptides [PDF]

Scientific Reports, 2020
AbstractAntimicrobial peptides (AMPs) are an important part of the human innate immune system for protection against bacterial infections, however the AMPs display varying degrees of activity against Staphylococcus aureus. Previously, we showed that inactivation of the ATP synthase sensitizes S.
Liu, Liping, Beck, Christian, Nøhr-Meldgaard, Katrine, Peschel, Andreas, Kretschmer, Dorothee, Ingmer, Hanne, Vestergaard, Martin   +6 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]

, 2012
Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G., Broek, L.A.M., van den, Chavaroche, A.A.E., Eggink, G.   +3 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo [PDF]

, 2016
Burkholderia cenocepacia, an opportunistic respiratory pathogen particularly relevant for cystic fibrosis patients, is difficult to eradicate due to its high level of resistance to most clinically relevant antimicrobials.
Azzalin, Alberto, Brackman, Gilles, Buroni, Silvia, Chiarelli, Laurent R, Coenye, Tom, Forneris, Federico, Israyilova, Aygun, Makarov, Vadim, Riabova, Olga, Riccardi, Giovanna, Savina, Sventlana, Scoffone, Viola C   +11 more
core   +2 more sources

Connection between antimicrobial venom peptides and bacterial ATP Synthase

The FASEB Journal, 2018
Background Antibiotic resistance is becoming a huge threat with devastating effects on public health and the global economy. Therefore, finding new alternatives to combat antibiotic resistant microbes is of paramount importance.
Hiba Syed, Zulfiqar Ahmad
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source