Results 51 to 60 of about 855,791 (338)

Thermally-Induced Lactosylation of Whey Proteins: Identification and Synthesis of Lactosylated β-lactoglobulin Epitope

Molecules, 2020
The high temperatures used in the production of milk may induce modifications in proteins structure. Due to occurrence of the Maillard reaction, lactose binds lysine residues in proteins, affecting the nutritional value.
Alessandra Gasparini, Sofie Buhler, Andrea Faccini, Stefano Sforza, Tullia Tedeschi   +4 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The Peptide Synthesis. II. Use of the Phenol Resin for the Peptide Synthesis [PDF]

Bulletin of the Chemical Society of Japan, 1968
Abstract The phenol resin is useful as support of the solid phase peptide synthesis. Its use is particularly advantageous for the synthesis of the N-protected peptide fragments, and those which have the intramolecular disulfide bond, such as oxytocin.
Murakami Masuo, Kohzi Nakano, Noriyoshi Inukai   +2 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Preparation of hexagonal GeO2 particles with particle size and crystallinity controlled by peptides, silk and silk-peptide chimeras [PDF]

, 2014
We demonstrate the use of silk based proteins to control the particle/crystallite size during GeO2 formation, using a bio-mimetic approach at circumneutral pH and ambient temperature. Multicrystalline GeO2 was prepared from germanium tetraethoxide (TEOG)
Avanzato, Belton, Brown, Brunner, Canabady-Rochelle, Carole C. Perry, Chiu, Cohen-Karni, Coradin, Davis, Devyatykh, Dickerson, Dickerson, Dickerson, Ellwood, Estefania Boix, Feng, Fleming, Foo, Gosline, Gulrajani, Inoue, Kanno, Kawai, Kim, Kim, Kim, Lawrence, Lippincott, Micoulaut, Mieszawska, Mieszawska, Murphy, Parker, Patwardhan, Perez-Rigueiro, Puddu, Puddu, Scherrer, Sewell, Slocik, Smith, Sofia, Valeria Puddu, Wu, Wu, Young, Zhou   +47 more
core   +1 more source

An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis [PDF]

Peptide Science, 2008
AbstractExpressed protein ligation (EPL) is a protein semisynthesis technique that allows the site‐specific introduction of unnatural amino acids and biophysical probes into proteins. In the present study, we illustrate the utility of the approach through the generation of two semisynthetic proteins bearing spectroscopic probes. Dihydrofolate reductase
Baldissera Giovani, Tom W. Muir, Maya Bar-Dagan, Jennifer J. Ottesen   +3 more
openaire   +3 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Synthesis of hippuric acid in liver homogenate [PDF]

, 1947
The synthesis of hippuric acid from benaoic acid and glycine resembles in several respects the synthesis of a peptide bond. A CONH group is formed, it is a to a carboxyl group, and the free energy of its formation is of the same order of magnitude.
Borsook, Henry, Dubnoff, Jacob W.
core  

Understanding Acid Lability of Cysteine Protecting Groups

Molecules, 2013
Cys-disulfide bonds contribute to the stabilization of peptide and protein structures. The synthesis of these molecules requires a proper protection of Cys residues, which is crucial to prevent side-reactions and also to achieve the correct Cys ...
Iván Ramos-Tomillero, Lorena Mendive-Tapia, Miriam Góngora-Benítez, Ernesto Nicolás, Judit Tulla-Puche, Fernando Albericio   +5 more
doaj   +1 more source