Results 191 to 200 of about 24,252 (260)

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, Volume 13, Issue 57, 14 October 2026.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Safe and Stable Germline Transmission of MSTN Mutations in Cattle

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT With the global population expected to reach 10 billion by 2050, sustainable livestock production is critical. Gene editing of the myostatin (MSTN) gene represents a promising strategy to enhance muscle growth in cattle. In this study, MSTN‐mutated founder (F0) cows were used to generate F1 offspring via ovum pick‐up, in vitro fertilization ...
Gyeong‐Min Gim, Bae Young Choi, Jeongbin Yi, Kyeong‐Hyeon Eom, Soo‐Young Yum, Dae‐Jin Jung, Do‐Yoon Kim, Bokyoung Yang, Jong‐Seo Kim, Donghwan Shim, Goo Jang   +10 more
wiley   +1 more source

Verrucacrylic Acids A and B From a Marine Sponge‐derived Verrucosispora sp. FIM06025

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Three new compounds, including two rare cyclopropane‐containing compounds, verrucacrylic acids A and B (1 and 2), and a new amino acid derivative (3), were isolated from Verrucosispora sp. FIM06025, 1 and 2 exhibited weak cytotoxic activity against HL‐60 and T47D. ABSTRACT Verrucosispora sp.
Minghong Chen, Chengzeng Zhou, Ru Lin, Yuan Yuan, Jian Zhou   +4 more
wiley   +1 more source

Advances in Peptide‐Targeted Fluorescent Probes for the Diagnosis and Therapy of Brain Disorders

ChemistryEurope, Volume 4, Issue 10, October 2026.
This review summarizes peptide‐based fluorescent probes for major brain diseases, such as Alzheimer's and Parkinson's. It highlights their precise biomarker targeting and high sensitivity for imaging pathological processes in vivo. These probes also show great potential for enabling theranostic applications, thereby offering real‐time monitoring and ...
Shuangjing Yang, Yuting Wang, Yongkang Yue, Fangjun Huo, Caixia Yin   +4 more
wiley   +1 more source

Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome.

J Clin Endocrinol Metab, 2015
Gumus Balikcioglu P, Balikcioglu M, Muehlbauer MJ, Purnell JQ, Broadhurst D, Freemark M, Haqq AM.   +6 more
europepmc   +1 more source

Satiety responsiveness following dietary exposure to ultra-processed foods differing in texture-derived eating rate: a secondary analysis of a randomized controlled crossover diet intervention. [PDF]

Eur J Nutr
van Bruinessen M, Liu Z, Heuven LAJ, Stieger M, Lasschuijt MP, Forde CG.   +5 more
europepmc   +1 more source

Modulation of taste responsiveness by the satiation hormone peptide YY.

FASEB J, 2013
La Sala MS, Hurtado MD, Brown AR, Bohórquez DV, Liddle RA, Herzog H, Zolotukhin S, Dotson CD.   +7 more
europepmc   +1 more source

The relationship between appetite hormones and body mass index in children with intoxication type metabolic diseases. [PDF]

Orphanet J Rare Dis
Koç N, Konyalıgil DB, Özen Yeşil B, Kaldırım B, Tel Adıgüzel K, Kıreker Köylü O, Kasapkara ÇS, Fırat Oğuz E, Eren F, Esgi M, Ünal Uzun Ö, Gündüz M.   +11 more
europepmc   +1 more source