Results 41 to 50 of about 11,450 (169)
mBio, 2016 Mycobacterium tuberculosis is a leading cause of death worldwide. The M. tuberculosis TAT (twin-arginine translocation) protein secretion system is present at the cytoplasmic membrane of mycobacteria and is known to transport folded proteins.
Manish Bhuwan +7 more
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A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. [PDF]
PLoS Pathogens, 2008 The final stage of bacterial cell division requires the activity of one or more enzymes capable of degrading the layers of peptidoglycan connecting two recently developed daughter cells. Although this is a key step in cell division and is required by all
Erik C Hett +3 more
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Coordinated peptidoglycan synthases and hydrolases stabilize the bacterial cell wall
Nature Communications, 2023 Abstract Peptidoglycan (PG) defines cell shape and protects bacteria against osmotic stress. The growth and integrity of PG require coordinated actions between synthases that insert new PG strands and hydrolases that generate openings to allow the insertion.
Huan Zhang +3 more
openaire +3 more sources
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
Nature Communications, 2017 MepS is a peptidoglycan (PG) cross-link specific hydrolase needed for cell wall expansion and its cellular levels must be tightly regulated. Here the authors present the structure of the MepS degrading protease Prc bound to its adaptor NlpI and propose a
Ming-Yuan Su +11 more
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Molecules, 2021 Clostridium perfringens autolysin (CpAcp) is a peptidoglycan hydrolase associated with cell separation, division, and growth. It consists of a signal peptide, ten SH3b domains, and a catalytic domain.
Yubao Shan +6 more
doaj +1 more source
Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]
BMC Genomics, 2016 The efficacy of antibiotics against bacterial infections is decreasing due to the development of resistance in bacteria, and thus, there is a need to search for potential alternatives to antibiotics. In this scenario, peptidoglycan hydrolases can be used as alternate antibacterial agents due to their unique property of cleaving peptidoglycan cell wall ...
Sharma, Ashok K. +4 more
openaire +2 more sources
More than just lysins: peptidoglycan hydrolases tailor the cell wall [PDF]
Current Opinion in Microbiology, 2011 Enzymes that degrade the peptidoglycan (PG) cell wall layer called PG hydrolases or autolysins are often thought of as destructive forces. Phages employ them to lyse their host for the release of virion particles and some bacteria secrete them to eliminate (lyse) their competition.
Tsuyoshi, Uehara, Thomas G, Bernhardt
openaire +2 more sources
Journal of BacteriologyThe peptidoglycan (PG) cell wall is a mesh-like layer that shapes bacteria and protects against osmotically induced lysis. PG is composed of glycan strands and peptide chains that link together to form a continuous layer that surrounds the cell.
Joseph C. Bryant +5 more
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. [PDF]
PLoS ONE, 2013 Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S.
Siqiang Niu +15 more
doaj +1 more source