Results 41 to 50 of about 26,717 (273)
The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides
International Journal of Molecular Sciences, 2020 Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development.
J. Lachowicz +8 more
semanticscholar +1 more source
Sequence Changes Modulate Peptoid Self-Association in Water
Frontiers in Chemistry, 2020 Peptoids, N-substituted glycine oligomers, are a class of diverse and sequence-specific peptidomimetics with wide-ranging applications. Advancing the functional repertoire of peptoids to emulate native peptide and protein functions requires engineering ...
Amelia A. Fuller +8 more
doaj +1 more source
Peptidomimetics in cancer targeting
Molecular Medicine, 2022 AbstractThe low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway ...
Mohammad Mahmoudi Gomari +9 more
openaire +3 more sources
Antioxidants, 2020 The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation.
S. La Manna +7 more
semanticscholar +1 more source
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites [PDF]
, 2014 N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub ...
Brannigan, JA +5 more
core +1 more source
Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury [PDF]
, 2020 Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and ...
Basta, Jeannine +5 more
core +1 more source
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing [PDF]
, 2018 Staphylococcus aureus is an important pathogen causing infections in humans and animals. Increasing problems with antimicrobial resistance has prompted the development of alternative treatment strategies, including antivirulence approaches targeting ...
Baldry, Mara +8 more
core +2 more sources
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4). [PDF]
, 2012 The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade.
Fujii, Nobutaka, Oishi, Shinya
core +1 more source
Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells.
Journal of the American Chemical Society, 2020 Peptides and peptidomimetics represent the middle space between small molecules and large proteins-they retain the relatively small size and synthetic accessibility of small molecules while providing high binding specificity for biomolecular partners ...
Daniel Y Yoo +5 more
semanticscholar +1 more source
Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]
, 2012 The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas +6 more
core +1 more source