Results 51 to 60 of about 26,717 (273)
Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
Beilstein Journal of Organic Chemistry, 2011 The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides ...
Anton V. Gulevich +5 more
doaj +1 more source
On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. [PDF]
, 2016 A Friedel-Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations
Curtin, Brice H +5 more
core +1 more source
Molecules, 2022 Dipeptidyl peptidase III (DPP III) was originally thought to be a housekeeping enzyme that contributes to intracellular peptide catabolism. More specific roles for this cytosolic metallopeptidase, in the renin-angiotensin system and oxidative stress ...
Marija Abramić, Dejan Agić
doaj +1 more source
Frontiers in Microbiology, 2019 Pseudomonas aeruginosa infection is a predominant cause of morbidity and mortality in patients with cystic fibrosis infection and with a compromised immune system.
Natalia Molchanova +6 more
doaj +1 more source
Backbone chemical shift assignments of human 14-3-3$\sigma$ [PDF]
, 2019 14-3-3 proteins are a group of seven dimeric adapter proteins that exert their biological function by interacting with hundreds of phosphorylated proteins, thus influencing their sub-cellular localization, activity or stability in the cell.
Boll, Emmanuelle +5 more
core +3 more sources
Covalent Peptide‐Based N‐Myc/Aurora‐A Inhibitors Bearing Sulfonyl Fluoride Warheads [PDF]
J Pept SciN‐Myc‐derived peptidomimetics bearing aryl sulfonyl fluoride warheads were shown to act as effective N‐Myc/Aurora‐A PPI inhibitors, selectively labelling Aurora‐A in a recognition‐directed manner. ABSTRACT Orthosteric inhibition of the N‐Myc/Aurora‐A protein–protein interaction (PPI) represents a potential mechanism by which degradation of N‐Myc can be
Dawber R +6 more
europepmc +2 more sources
Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides
Frontiers in Chemistry, 2020 A4K14-citropin 1.1 is a structurally optimized derivative derived from amphibians' skin secreta peptide Citropin, which exhibits broad biological activities.
Nan Wang +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2022 Protein–protein interactions (PPI) of co-stimulatory molecules CD2-CD58 are important in the early stage of an immune response, and increased expression of these co-stimulatory molecules is observed in the synovial region of joints in rheumatoid ...
Achyut Dahal +7 more
doaj +1 more source
Molecules, 2022 Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal X-P-K/R motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N-terminal region of its substrates.
Guangping Dong +4 more
doaj +1 more source
The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner. [PDF]
, 2013 The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae.
Bojsen, Rasmus +4 more
core +1 more source