Results 91 to 100 of about 5,492 (203)

Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides [PDF]

, 2017
This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self ...
Hoogenboom, Richard, Schlaad, Helmut
core   +2 more sources

Aspartimide Formation and Its Prevention in Fmoc Chemistry Solid Phase Peptide Synthesis

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
Aspartimide formation remains a persistent challenge in Fmoc solid phase peptide synthesis. This review surveys strategies to prevent aspartimide formation, covering protecting group design, backbone protection, and alternative deprotection approaches.
Marco J. W. Kong, Tim J. H. P. van den Braak, Kevin Neumann   +2 more
wiley   +1 more source

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.

PLoS ONE, 2014
Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity ...
Wei Huang, Jiwon Seo, Stephen B Willingham, Ann M Czyzewski, Mark L Gonzalgo, Irving L Weissman, Annelise E Barron   +6 more
doaj   +1 more source

Gold amides as anticancer drugs: synthesis and activity studies [PDF]

, 2013
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery.
Amagai, Amruta Shrikhande, Bjornstedt, Chen, Chris Gallop, Cox, Davis, Eddy M. E. Viseux, Eva Hoffmann, Fricker, Gabbiani, Helen Yong, Hickey, Hill, Lemke, Lima, Mariusz Bobin, Mark Roe, Mezailles, Modica-Napolitano, Omata, Orvig, Ott, Patra, Poole, Rebecca Gates, Shuvashri Chaudhuri, Sonya Newcombe, Stallings-Mann, Thaqi, Wetzel, Yan, Yannick Pace, Zhang, Zhang   +34 more
core   +1 more source

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W., Han K., Ho A., Park J., Theodore L.   +4 more
core   +1 more source

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Nature Communications, 2018
Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt ...
Jeffrey A. Schneider, Timothy W. Craven, Amanda C. Kasper, Chi Yun, Michael Haugbro, Erica M. Briggs, Vladimir Svetlov, Evgeny Nudler, Holger Knaut, Richard Bonneau, Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan   +12 more
doaj   +1 more source

Protein Transduction Method for Cerebrovascular Disorders [PDF]

, 2009
Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane.
Arimitsu, Seiji, Date, Isao, Ichikawa, Tomotsugu, Matsui, Hideki, Ogawa, Tomoyuki, Ono, Shigeki, Onoda, Keisuke, Sugiu, Kenji, Tokunaga, Koji, Tomizawa, Kazuhito   +9 more
core   +1 more source

Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate [PDF]

, 2017
Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate was synthesized via Ugi four component (4C) reaction at ambient temperature. The protocol employs a reaction between formaldehyde, furfurylamine, acrylic acid, and ethyl 2-isocyanoacetate.
Saha, Nabanita, Shimoga Dinesh, Ganesh, Sáha, Petr, Zuckermann, Ronald N.   +3 more
core   +1 more source

Bacterial membrane activity of α-peptide/β-peptoid chimeras: Influence of amino acid composition and chain length on the activity against different bacterial strains

BMC Microbiology, 2011
Background Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual ...
Gram Lone, Franzyk Henrik, Knapp Kolja M, Hein-Kristensen Line   +3 more
doaj   +1 more source

Dinuclear Lanthanide (III) coordination polymers in a domino reaction [PDF]

, 2015
A systematic study was performed to further optimise the catalytic room-temperature synthesis of trans-4,5- diaminocyclopent-2-enones from 2-furaldehyde and primary or secondary amines under a non-inert atmosphere. For this purpose, a series of dinuclear
Abdul-Sada, Alaa, Akien, Geoffrey R, Griffiths, Kieran, Kostakis, George E, Kourkoumelis, Nikolaos, Loukopoulos, Edward   +5 more
core   +2 more sources