Results 91 to 100 of about 5,562 (217)

Aromatic Amide Foldamers Show Conformation‐Dependent Electronic Properties

ChemPhysChem, Volume 26, Issue 24, December 16, 2025.
Aromatic foldamers with a trans configuration show enhanced conductance compared to shorter foldamers with a cis configuration due to efficient through‐bond electron tunneling. Electron transport in organic molecules and biomolecules is governed by electronic structure and molecular conformations.
Rajarshi Samajdar, Xiaolin Liu, Kazusa Kuyama, Yui Kidokoro, Fumi Takeda, Iwao Okamoto, Masatoshi Kawahata, Kosuke Katagiri, Jeffrey S. Moore, Aya Tanatani, Charles M. Schroeder   +10 more
wiley   +1 more source

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.

PLoS ONE, 2014
Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity ...
Wei Huang, Jiwon Seo, Stephen B Willingham, Ann M Czyzewski, Mark L Gonzalgo, Irving L Weissman, Annelise E Barron   +6 more
doaj   +1 more source

Self-assembly of bioactive peptides, peptide conjugates, and peptide-mimetic materials [PDF]

, 2017
Molecular self-assembly is a multi-disciplinary field of research, with potential chemical and biological applications. One of the main driving forces of self-assembly is molecular amphiphilicity, which can drive formation of complex and stable ...
Ahmed, Arslan, Bae, Boato, Branco, Brown, Butterfoss, Castelletto, Castelletto, Castelletto, Cavalli, Charlotte J. C. Edwards-Gayle, Cheng, Chu-Kung, Cooke, Cui, Das, Dasgupta, DeForest, Dehsorkhi, Dehsorkhi, Deres, Engler, Fetsch, Fu, Gardner, Guo, Hamley, Hamley, Hamley, Hamley, Hamley, Hamley, Hartgerink, Hartweg, Heinis, Hersel, Hill, Hu, Hubbell, Hutchinson, Hynes, Ian W. Hamley, Jing, Johnson, Jones, Karakoti, Keung, Kiley, Kim, Kirkham, Kita-Tokarczyk, Knop, Kolate, Krug, Lau, Lee, Leupold, Li, Lintner, Liu, Liu, Lutolf, Lutolf, Löwik, Löwik, Makovitzki, Mandal, Marsh, Mas-Moruno, Matson, Matson, Matsuda, Matsumoto, McGregor, Meijer, Middleton, Miller, Miravet, Missirlis, Murnen, Murphy, Nam, Nishiyama, Oku, Pakalns, Pasut, Pelegri-Oday, Peppas, Petka, Place, Place, Qiu, Rice, Robertson, Rosales, Ruoslahti, Ruoslahti, Sanii, Shen, Sheu, Silva, Singh, Slaughter, Spoerke, Stahl, Stendahl, Stupp, Sun, Thiele, Tirrell, Torchilin, Tu, Tysseling-Mattiace, Tzokova, Tzokova, Van Vlierberghe, Vauthey, Wadia, Webster, Wilson, Wiradharma, Wiradharma, Yu, Zhang, Zhao, Zhao, Zhou   +127 more
core   +1 more source

The Role of Intimate Dipole Carbonyl–Carbonyl and Hydrogen–Carbonyl Interactions in the Stereocomplexation and Crystallization: The Case of Poly(Cyclohexene Carbonate)

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Isotactic poly(cyclohexene carbonate) crystalizes both as enantiopure polymer and upon stereocomplexation of the two opposite enantiomers. Both structures are characterized by multiple H‐‐‐O═C tight attractive interactions, whereas in the stereocomplex a tight interdigitation of the two enantiomeric chains occurs due to additional intimate dipole ...
Massimo Christian D'Alterio, Miriam Scoti, Rocco Di Girolamo, Giovanni Talarico, Geoffrey W. Coates, Claudio De Rosa   +5 more
wiley   +1 more source

Design and Synthesis of a Novel N-(1H-tetrazol-5-yl)methyl Cyclic Peptoid Using Nosyl-protected N-(1-trityl-1H-tetrazol-5-yl)methyl Substituted Glycine [PDF]

, 2017
: A solid phase synthesis of a cyclic peptoid bearing (1H-tetrazol-5-yl)methyl as N-substituent has been developed employing the monomer approach.
Krishnamurthy, M., Narendra, N., Prabhu, G., Samarasimhareddy, M., Sureshbabu, V.V.   +4 more
core   +1 more source

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Nature Communications, 2018
Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt ...
Jeffrey A. Schneider, Timothy W. Craven, Amanda C. Kasper, Chi Yun, Michael Haugbro, Erica M. Briggs, Vladimir Svetlov, Evgeny Nudler, Holger Knaut, Richard Bonneau, Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan   +12 more
doaj   +1 more source

Gold amides as anticancer drugs: synthesis and activity studies [PDF]

, 2013
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery.
Amagai, Amruta Shrikhande, Bjornstedt, Chen, Chris Gallop, Cox, Davis, Eddy M. E. Viseux, Eva Hoffmann, Fricker, Gabbiani, Helen Yong, Hickey, Hill, Lemke, Lima, Mariusz Bobin, Mark Roe, Mezailles, Modica-Napolitano, Omata, Orvig, Ott, Patra, Poole, Rebecca Gates, Shuvashri Chaudhuri, Sonya Newcombe, Stallings-Mann, Thaqi, Wetzel, Yan, Yannick Pace, Zhang, Zhang   +34 more
core   +1 more source

Bacterial membrane activity of α-peptide/β-peptoid chimeras: Influence of amino acid composition and chain length on the activity against different bacterial strains

BMC Microbiology, 2011
Background Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual ...
Gram Lone, Franzyk Henrik, Knapp Kolja M, Hein-Kristensen Line   +3 more
doaj   +1 more source

Protein Transduction Method for Cerebrovascular Disorders [PDF]

, 2009
Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane.
Arimitsu, Seiji, Date, Isao, Ichikawa, Tomotsugu, Matsui, Hideki, Ogawa, Tomoyuki, Ono, Shigeki, Onoda, Keisuke, Sugiu, Kenji, Tokunaga, Koji, Tomizawa, Kazuhito   +9 more
core   +1 more source

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W., Han K., Ho A., Park J., Theodore L.   +4 more
core   +1 more source