Results 11 to 20 of about 2,770 (210)
Molecules, 2021 Peptoids (oligo N-substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they are resistant to proteolytic degradation.
Jamie Toole +5 more
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Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus
Microbiology Spectrum, 2022 Staphylococcus aureus is one of the most common pathogens associated with infection in wounds. The current standard of care uses a combination of disinfection and drainage followed by conventional antibiotics such as methicillin.
Aaron B. Benjamin +10 more
doaj +1 more source
Frontiers in Chemistry, 2020 Peptoids hold status as peptide-mimetics with versatile biological applications due to their proteolytic stability and structural diversity. Among those that have been studied in different biological systems, are peptoids with dominant balanced ...
Abdullah Lone +5 more
doaj +1 more source
Sequence Changes Modulate Peptoid Self-Association in Water
Frontiers in Chemistry, 2020 Peptoids, N-substituted glycine oligomers, are a class of diverse and sequence-specific peptidomimetics with wide-ranging applications. Advancing the functional repertoire of peptoids to emulate native peptide and protein functions requires engineering ...
Amelia A. Fuller +8 more
doaj +1 more source
Direct Selection of Functional De Novo Macrocycles for Activation of On-Cellulo Insulin Receptor. [PDF]
Angew Chem Int Ed EnglA live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Kuo YH, Mihara E, Takagi J, Suga H.
europepmc +3 more sources
Fragmentation of Peptoids Containing a Basic Residue [PDF]
, 2023 Peptoids, also referred to as poly (N-substituted glycines) belong to a class of peptidomimetic polymers whose side chain is appended to the nitrogen atom of the peptoid backbone as opposed to the ɑ-carbon in peptides.
Ren, Jianhua +2 more
core +2 more sources
, 2016 Foldamers are an intriguing family of biomimetic oligomers that exhibit a propensity to adopt stable secondary structures. N-Substituted glycine oligomers, or “peptoids”, are a prototypical example of these foldamer systems and are known to form a helix ...
Sung Bin Y. Shin (2155738) +3 more
core +5 more sources
Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology
Molecules, 2018 Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids).
Hannah L. Bolt +3 more
doaj +1 more source
In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]
PLoS ONE, 2016 Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski +7 more
doaj +1 more source
Antibiotics, 2022 Peptoids are peptidomimetics that have attracted considerable interest as a promising class of antimicrobials against multi-drug-resistant bacteria due to their resistance to proteolysis, bioavailability, and thermal stability compared to their ...
Ghayah Bahatheg +5 more
doaj +1 more source