Results 41 to 50 of about 2,770 (210)
β-Peptoid Foldamers at Last [PDF]
Accounts of Chemical Research, 2015 For a long time, peptides were considered unsuitable for drug development due to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However, this paradigm has changed significantly in the past decade with the approval of numerous antibodies and proteins as drugs.
Laursen, Jonas S +2 more
openaire +3 more sources
Frontiers in Chemistry, 2020 Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria.
Abshar Hasan +11 more
doaj +1 more source
Systematic Investigation on Acid-Catalyzed Truncation of N-Acylated Peptoids. [PDF]
Int J Mol SciPeptoids have emerged as a useful alternative to peptides. However, N-acylated peptoids have occasionally undergone truncation at the terminal peptoid unit under acidic conditions.
Piao R, Kwon YU.
europepmc +2 more sources
Frontiers in Chemistry, 2023 Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines.
Ricelia González +9 more
doaj +1 more source
Characterization of Novel Antimicrobial Peptoids [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Peptoids differ from peptides in that peptoids are composed of N-substituted rather than alpha-carbon-substituted glycine units. In this paper we report the in vitro and in vivo antibacterial activities of several antibacterial peptoids discovered by screening combinatorial chemistry libraries for bacterial growth ...
B, Goodson +12 more
openaire +2 more sources
Helical Folding of Abiotic Chiral Poly(phosphodiester)s
Chemistry – A European Journal, EarlyView.Design and structural analysis of a new class of phosphodiester foldamers are presented. These oligomers that fold into single helical architecture showed length and temperature stability dependence comparable to DNA duplexes. ABSTRACT Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence
Ranajit Barman +3 more
wiley +1 more source
Enantiorecognition ability of peptoids with a-chiral, aromatic side chains [PDF]
, 2011 Enantiorecognition ability of peptoids with a-chiral, aromatic side ...
梁图 +5 more
core
Pharmaceuticals, 2012 Cell penetrating peptoids (CPPos) are potent mimics of the corresponding cell penetrating peptides (CPPs). The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of
Dominik K. Kölmel +6 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach
Beilstein Journal of Organic Chemistry, 2015 A library of ten 1,3-diyne-linked peptoids has been synthesized through an Ugi four-component reaction (U-4CR) followed by a copper-catalysed alkyne homocoupling (Glaser reaction). The short and chemoselective reaction sequence allows generating diverse (
Martin C. N. Brauer +4 more
doaj +1 more source