Results 21 to 30 of about 5,830 (259)

Review: Structure-Activity Relationship of Antimicrobial Peptoids

Pharmaceutics, 2023
Due to their broad-spectrum activity against Gram-negative and Gram-positive bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs have emerged as prospective therapies for treating illnesses brought on by multi-drug resistant ...
Priscilla L. Nyembe, Thandokuhle Ntombela, Maya M. Makatini   +2 more
doaj   +1 more source

Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

Molecules, 2018
Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids).
Hannah L. Bolt, Laurens H. J. Kleijn, Nathaniel I. Martin, Steven L. Cobb   +3 more
doaj   +1 more source

Membrane‐acting biomimetic peptoids against visceral leishmaniasis

FEBS Open Bio, 2023
Visceral leishmaniasis (VL) is among the most neglected tropical diseases in the world. Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell‐permeating peptides a logical choice to address ...
Vivek Kumar, Jennifer S. Lin, Natalia Molchanova, John A. Fortkort, Carolin Reckmann, Stefan Bräse, Håvard Jenssen, Annelise E. Barron, Archana Chugh   +8 more
doaj   +1 more source

Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies

Antibiotics, 2022
Peptoids are peptidomimetics that have attracted considerable interest as a promising class of antimicrobials against multi-drug-resistant bacteria due to their resistance to proteolysis, bioavailability, and thermal stability compared to their ...
Ghayah Bahatheg, Rajesh Kuppusamy, Muhammad Yasir, David StC. Black, Mark Willcox, Naresh Kumar   +5 more
doaj   +1 more source

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]

PLoS ONE, 2016
Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski, Håvard Jenssen, Christopher D Fjell, Matt Waldbrook, Nathaniel P Chongsiriwatana, Eddie Yuen, Robert E W Hancock, Annelise E Barron   +7 more
doaj   +1 more source

Aromatic Amide Foldamers Show Conformation-Dependent Electronic Properties. [PDF]

Chemphyschem
Aromatic foldamers with a trans configuration show enhanced conductance compared to shorter foldamers with a cis configuration due to efficient through‐bond electron tunneling. Electron transport in organic molecules and biomolecules is governed by electronic structure and molecular conformations.
Samajdar R, Liu X, Kuyama K, Kidokoro Y, Takeda F, Okamoto I, Kawahata M, Katagiri K, Moore JS, Tanatani A, Schroeder CM.   +10 more
europepmc   +2 more sources

Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides

Molecules, 2018
Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities.
Assunta D’Amato, Giorgio Della Sala, Irene Izzo, Chiara Costabile, Yuichi Masuda, Francesco De Riccardis   +5 more
doaj   +1 more source

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids

Pharmaceuticals, 2021
Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections.
Gill Diamond, Natalia Molchanova, Claudine Herlan, John A. Fortkort, Jennifer S. Lin, Erika Figgins, Nathen Bopp, Lisa K. Ryan, Donghoon Chung, Robert Scott Adcock, Michael Sherman, Annelise E. Barron   +11 more
doaj   +1 more source

Real‐Time Monitoring of Multitarget Antimicrobial Mechanisms of Peptoids Using Label‐Free Imaging with Optical Diffraction Tomography

Advanced Science, 2023
Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug‐resistant bacteria. As a mimic of AMPs, peptoids with N‐substituted glycine backbone have been utilized for antimicrobials with resistance against proteolytic ...
Minsang Kim, Yeongmi Cheon, Dongmin Shin, Jieun Choi, Josefine Eilsø Nielsen, Myeong Seon Jeong, Ho Yeon Nam, Sung‐Hak Kim, Reidar Lund, Håvard Jenssen, Annelise E. Barron, Seongsoo Lee, Jiwon Seo   +12 more
doaj   +1 more source

Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets. [PDF]

, 2019
The ability of antibodies to bind a wide variety of analytes with high specificity and high affinity makes them ideal candidates for therapeutic and diagnostic applications. However, the poor stability and high production cost of antibodies have prompted
Abate, Adam R, Cardiel, Joshua, Chen, Chun-Long, Chen, Yulin, Connolly, Michael D, Dehigaspitiya, Dilani C, Grzincic, Elissa M, Jian, Tengyue, Karbaschi, Mohsen, Kim, Jae Hong, Kim, Samuel C, Kirshenbaum, Kent, Kline, Mark A, Liu, Jianfang, Murray, Daniel J, Ren, Gang, Tresca, Blakely W, Udumula, Venkatareddy, Yun, Lisa, Zuckermann, Ronald N   +19 more
core   +1 more source