Results 51 to 60 of about 5,830 (259)

Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids

Frontiers in Chemistry, 2023
Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines.
Ricelia González, Juliana Murillo-López, Walter Rabanal-León, Luis Prent-Peñaloza, Odette Concepción, Pedro Olivares, Yorley Duarte, Alexander F. de la Torre, Margarita Gutiérrez, Julio Caballero   +9 more
doaj   +1 more source

Targeted Drug Delivery using Peptoid Based Nanospheres [PDF]

, 2016
While medicine has improved greatly in the last couple of decades, there are negative side effects that accompany many drugs. Undesirable side effects could be greatly reduced if non-systemic drug delivery systems were used because the medicine would ...
Smith, Kaylee J
core   +2 more sources

Self-assembly of bioactive peptides, peptide conjugates, and peptide-mimetic materials [PDF]

, 2017
Molecular self-assembly is a multi-disciplinary field of research, with potential chemical and biological applications. One of the main driving forces of self-assembly is molecular amphiphilicity, which can drive formation of complex and stable ...
Ahmed, Arslan, Bae, Boato, Branco, Brown, Butterfoss, Castelletto, Castelletto, Castelletto, Cavalli, Charlotte J. C. Edwards-Gayle, Cheng, Chu-Kung, Cooke, Cui, Das, Dasgupta, DeForest, Dehsorkhi, Dehsorkhi, Deres, Engler, Fetsch, Fu, Gardner, Guo, Hamley, Hamley, Hamley, Hamley, Hamley, Hamley, Hartgerink, Hartweg, Heinis, Hersel, Hill, Hu, Hubbell, Hutchinson, Hynes, Ian W. Hamley, Jing, Johnson, Jones, Karakoti, Keung, Kiley, Kim, Kirkham, Kita-Tokarczyk, Knop, Kolate, Krug, Lau, Lee, Leupold, Li, Lintner, Liu, Liu, Lutolf, Lutolf, Löwik, Löwik, Makovitzki, Mandal, Marsh, Mas-Moruno, Matson, Matson, Matsuda, Matsumoto, McGregor, Meijer, Middleton, Miller, Miravet, Missirlis, Murnen, Murphy, Nam, Nishiyama, Oku, Pakalns, Pasut, Pelegri-Oday, Peppas, Petka, Place, Place, Qiu, Rice, Robertson, Rosales, Ruoslahti, Ruoslahti, Sanii, Shen, Sheu, Silva, Singh, Slaughter, Spoerke, Stahl, Stendahl, Stupp, Sun, Thiele, Tirrell, Torchilin, Tu, Tysseling-Mattiace, Tzokova, Tzokova, Van Vlierberghe, Vauthey, Wadia, Webster, Wilson, Wiradharma, Wiradharma, Yu, Zhang, Zhao, Zhao, Zhou   +127 more
core   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

The Role of Intimate Dipole Carbonyl–Carbonyl and Hydrogen–Carbonyl Interactions in the Stereocomplexation and Crystallization: The Case of Poly(Cyclohexene Carbonate)

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Isotactic poly(cyclohexene carbonate) crystalizes both as enantiopure polymer and upon stereocomplexation of the two opposite enantiomers. Both structures are characterized by multiple H‐‐‐O═C tight attractive interactions, whereas in the stereocomplex a tight interdigitation of the two enantiomeric chains occurs due to additional intimate dipole ...
Massimo Christian D'Alterio, Miriam Scoti, Rocco Di Girolamo, Giovanni Talarico, Geoffrey W. Coates, Claudio De Rosa   +5 more
wiley   +2 more sources

Cell Penetrating Peptoids (CPPos): Synthesis of a Small Combinatorial Library by Using IRORI MiniKans

Pharmaceuticals, 2012
Cell penetrating peptoids (CPPos) are potent mimics of the corresponding cell penetrating peptides (CPPs). The synthesis of diverse oligomeric libraries that display a variety of backbone scaffolds and side-chain appendages are a very promising source of
Dominik K. Kölmel, Daniel Fürniss, Steven Susanto, Andrea Lauer, Clemens Grabher, Stefan Bräse, Ute Schepers   +6 more
doaj   +1 more source

Design and Synthesis of a Novel N-(1H-tetrazol-5-yl)methyl Cyclic Peptoid Using Nosyl-protected N-(1-trityl-1H-tetrazol-5-yl)methyl Substituted Glycine [PDF]

, 2017
: A solid phase synthesis of a cyclic peptoid bearing (1H-tetrazol-5-yl)methyl as N-substituent has been developed employing the monomer approach.
Krishnamurthy, M., Narendra, N., Prabhu, G., Samarasimhareddy, M., Sureshbabu, V.V.   +4 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach

Beilstein Journal of Organic Chemistry, 2015
A library of ten 1,3-diyne-linked peptoids has been synthesized through an Ugi four-component reaction (U-4CR) followed by a copper-catalysed alkyne homocoupling (Glaser reaction). The short and chemoselective reaction sequence allows generating diverse (
Martin C. N. Brauer, Ricardo A. W. Neves Filho, Bernhard Westermann, Ramona Heinke, Ludger A. Wessjohann   +4 more
doaj   +1 more source

Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids

Molecules, 2021
Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation.
Claudine Nicole Herlan, Anna Sonnefeld, Thomas Gloge, Julian Brückel, Luisa Chiara Schlee, Claudia Muhle-Goll, Martin Nieger, Stefan Bräse   +7 more
doaj   +1 more source