Results 71 to 80 of about 2,770 (210)
Smallest Peptoids with Antiproliferative Activity on Human Neoplastic Cells [PDF]
, 2016 Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines.
Carlos Mas-Moruno (1659775) +6 more
core +1 more source
Broad-Spectrum Activity of Antimicrobial Peptoids
Medical Sciences Forum, 2022 Antimicrobial peptides (AMPs) are naturally occurring host defense molecules, representing an evolutionarily ancient, innate immune mechanism against pathogenic infection.
Gill Diamond +4 more
doaj +1 more source
Cancer Nexus, Volume 2, Issue 2, April 2026.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Cis–Trans Amide Bond Rotamers in β-Peptoids and Peptoids: Evaluation of Stereoelectronic:Effects in Backbone and Side Chains [PDF]
, 2013 Non-natural peptide analogs have significant potential for the development of new materials and pharmacologically active ligands. One such architecture, the β-peptoids (N-alkyl-β-alanines), has found use in a variety of biologically active compounds, but
Laursen, Jonas S. +5 more
core +1 more source
Solid-Phase Synthesis and Circular Dichroism Study of β-ABpeptoids
Molecules, 2019 The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on α-ABpeptoids, oligomers of N-alkylated β2-homoalanines and found that due to the presence ...
Ganesh A. Sable +2 more
doaj +1 more source
Frontiers in Microbiology, 2020 Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials.
Jasmeet Singh Khara +8 more
doaj +1 more source
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality
Nature CommunicationsA long-standing challenge in bioinspired materials is to design and synthesize synthetic materials that mimic the sophisticated structures and functions of natural biomaterials, such as helical protein assemblies that are important in biological systems.
Renyu Zheng +8 more
doaj +1 more source
A Peptoid-Based Fluorescent Sensor for Cyanide Detection
Molecules, 2016 Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet.
Bumhee Lim, Jeeyeon Lee
doaj +1 more source
Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics
Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins +3 more
wiley +1 more source