Results 71 to 80 of about 5,830 (259)
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, Volume 59, Issue 2, February 2026.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein [PDF]
, 2014 Pharmacological chaperones are small molecules that bind to proteins and stabilize them against thermal denaturation or proteolytic degradation, as well as assist or prevent certain protein-protein assemblies. These activities are being exploited for the
Burlak, Christopher +8 more
core +1 more source
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
Advanced Materials, Volume 38, Issue 4, 16 January 2026.Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon +5 more
wiley +1 more source
Small StructuresControlling chromophore chirality in three‐dimensional space is crucial for understanding the structure–chiroptical relationship. Such control enables the prediction of ideal materials for use in chiral photonic applications.
Jinyoung Oh +7 more
doaj +1 more source
A Peptoid Ribbon Secondary Structure [PDF]
Angewandte Chemie International Edition, 2013 foldamers that have been shown to possess numerous biological functions and could find use in a range of fundamental and applied contexts as bio-inspired materials. Peptoids are highly attractive scaffolds for such purposes, as their non-native backbones are resistant to proteolytic degradation and their straightforward, modular synthesis enables the ...
J Aaron, Crapster +2 more
openaire +2 more sources
A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids
Frontiers in Chemistry, 2020 Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy +5 more
doaj +1 more source
Non-natural protein mimetics for the treatment of Alzheimer\u27s disease [PDF]
, 2011 Alzheimer\u27s disease (AD) is a slow degenerative disease that causes memory loss and eventually leads to death. AD is caused by the aggregation of the amyloid-beta protein, found on the outside of brain cells; once the amyloid-beta protein begins to ...
Brown, Jasmine +4 more
core +1 more source
Solid-Phase Insertion of N-mercaptoalkylglycine Residues into Peptides
Molecules, 2019 N-mercaptoalkylglycine residues were inserted into peptides by reacting N-free amino groups of peptides, which were initially synthesized on 2-chlorotrityl resin (Cltr) using the Fmoc/tBu method, with bromoacetic acid and subsequent nucleophilic ...
Spyridon Mourtas +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 The synthesis and conformational analysis of the first series of peptoid oligomers composed of consecutive N-(alkylamino)glycine units is investigated. We demonstrate that N-(methylamino)glycine homooligomers can be readily synthesized in solution using ...
Maxime Pypec +3 more
doaj +1 more source
Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs
Separations, 2021 Membranes for use in high gas exchange lung applications are riddled with fouling. The goal of this research is to create a membrane that can function in an artificial lung until the actual lung becomes available for the patient.
Nawaf Alshammari +2 more
doaj +1 more source