Results 81 to 90 of about 5,830 (259)
Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation [PDF]
, 2014 Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an
Elduque Busquets, Xavier +2 more
core +2 more sources
Synthesis of Boron-Containing Primary Amines [PDF]
, 2013 [[abstract]]In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl
Baxter +8 more
core +2 more sources
Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.Abstract Background We previously demonstrated that a peptoid (LPFFA) prevents Aβ binding to human apoE producing cognitive rescue and reduced Aβ pathology on AD mouse models. We have now developed specific peptides that disrupt α‐helices essential for apoE conformation and pathological function; and tested, in cerebral amyloid angiopathy (CAA) TgSwDI ...
Fernando Goni +7 more
wiley +1 more source
Promising Antibiofilm Activity of Peptidomimetics
Frontiers in Microbiology, 2018 Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss.
Rafael Gomes Von Borowski +4 more
doaj +1 more source
Frontiers in Microbiology, 2020 Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials.
Jasmeet Singh Khara +8 more
doaj +1 more source
A Peptoid-Based Fluorescent Sensor for Cyanide Detection
Molecules, 2016 Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet.
Bumhee Lim, Jeeyeon Lee
doaj +1 more source
Protein Isolation Using Peptoid Based Affinity Chromatography [PDF]
, 2013 Protein purification is essential for advancements in biotechnology. There are several different methods employed in purifying a particular protein from a complex sample such as a cell lysate.
Dunn, Megan
core +1 more source
Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics
Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 269-278, December 2025.ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li +4 more
wiley +1 more source
Molecules, 2007 Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj +1 more source
Characterization of an Affitoid Variable Region to be used for MDM-2 Detection in ELISA Microarray [PDF]
, 2013 Sandwich enzyme-linked immunosorbent assay (ELISA) microarray using peptoid-based affinity reagents, referred to as affitoids, is potentially a very powerful tool for the early detection of cancer and other complex diseases. Current detection methods for
Reinhard, Graham
core +1 more source