Results 101 to 110 of about 8,010,517 (281)

Impact of Perceived Organisational Support on Employee Career Goals

open access: yesJournal of Human Resource Management Perspectives
This research investigates the impact of Perceived Organisational Support (POS) on career goal formulation and pursuit, with a focus on Sri Lankan marine engineers. Career goals are essential to professional growth, driving motivation, job satisfaction, and long-term career fulfilment. The study explores how POS, personal ambition, and external factors
Enoka Siriwardena, Samantha Rathnayaka
openaire   +1 more source

Perceived Organisational Support, Work Engagement and Organisational Citizenship Behaviour of Nurses at Victoria Hospital

open access: yesJournal of Psychology, 2013
This study explored the relationship between perceived organisational support, work engagement and organisational citizenship behaviour amongst nurses at the Victoria hospital in Alice, Eastern Cape, South Africa. Simple random sampling was used to draw a sample of n=106.
Dumisani Mathumbu, Nicole Dodd
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Leadership, Perceived Organisational Support and Employee Wellbeing Experimental Study

open access: yes, 2021
The project is interested in experimentally investigating the link between leadership style and employee wellbeing through perceived organisational ...
Ana C. Leite   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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