Results 61 to 70 of about 32,809 (256)

The role of perceived organisational support on technostress and work–family conflict

SA Journal of Industrial Psychology
Orientation: The role of workplace support has been well established; however, with tech-driven hybrid work settings, technostress makes managing work-family conflict daunting for employees. Research purpose: This study investigates the role of perceived organisational support (POS) in the relationship between technostress and work–family conflict ...
Chenè E. Ward, Martha Harunavamwe
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Relationship between Caring for Employees and the Well-being of the Organisation

Organizacijų Vadyba: Sisteminiai Tyrimai, 2020
The aim of this paper is to better understand the meaning of caring for employees at the organisational level as well as to disclose its relationship with the well-being of the organisation.
Poškienė Eglė, Coudounaris Dafnis N., Kazlauskaitė Rūta   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Revisiting Flexible Work: Untangling the Roles of Work–Family Conflict, Organisational Support, and Gender Attitudes in Women’s Work Engagement

JISR Management and Social Sciences & Economics
This study examines how flexible work arrangements influence women’s work engagement, with work–family conflict as a mediating mechanism and perceived organisational support and gender role attitudes as key contextual factors.
Yusra Shehzadi, Prof. Dr. Ravinder Rena, Kehkashan Rani   +2 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

‘I’ve been working in TV for 10 years and I’ve never had that’: fostering perceived organisational support (POS) among skilled contingent workers in the television industry

Journal of the British Academy
This article reports key findings from a pilot project to design, develop, and test an intervention aimed at increasing perceived organisational support among television freelancers.
Richard Wallis
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The influence of perceived organizational support on employee engagement of La Oma Cafe & Hotel

Journal of Management Small and Medium Enterprises (SME's)
This study examines the extent to which perceived organizational support shapes employee engagement within the hospitality sector, drawing on a case study conducted at La Oma Café & Hotel.
Simfoni Permata Mustikasari, Moh Benny Alexandri, Pratami Wulan Tresna   +2 more
doaj   +1 more source