Results 71 to 80 of about 8,010,517 (281)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Relationship between Caring for Employees and the Well-being of the Organisation

Organizacijų Vadyba: Sisteminiai Tyrimai, 2020
The aim of this paper is to better understand the meaning of caring for employees at the organisational level as well as to disclose its relationship with the well-being of the organisation.
Poškienė Eglė, Coudounaris Dafnis N., Kazlauskaitė Rūta   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Factors Influencing the Utilisation of High-Performance Computing (HPC) Systems in Higher Education Institutions

International Journal of Applied Research in Business and Management
Understanding how organisational support, perceived ease of use, and perceived usefulness influence the actual use of a High-Performance Computing (HPC) system sheds light on its adoption within a higher education institution.
Reginald Mulalo Ndwamai, Hlanganipai Ngirande   +1 more
doaj   +1 more source

The influence of perceived organisation support on employees engagement in Tanzania: a case of SMEs

Pressacademia, 2023
Purpose- For the organization to strive in today's competitive environment, managers should provide a working environment that is conducive and supportive to its members/employees. Human beings like to be recognized, valued, and taken care of while they are performing their duties.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The effect of leadership on public service motivation: a multiple embedded case study in Morocco

BMJ Open, 2020
Objectives We aimed at exploring the underlying mechanisms and contextual conditions by which leadership may influence ‘public service motivation’ of health providers in Moroccan hospitals.Design We used the realist evaluation (RE) approach in the ...
Bruno Marchal, Wim Van Damme, Zakaria Belrhiti, Abdelmounim Belalia   +3 more
doaj   +1 more source

The role of perceived organisational support on technostress and work–family conflict

SA Journal of Industrial Psychology
Orientation: The role of workplace support has been well established; however, with tech-driven hybrid work settings, technostress makes managing work-family conflict daunting for employees. Research purpose: This study investigates the role of perceived organisational support (POS) in the relationship between technostress and work–family conflict ...
Chenè E. Ward, Martha Harunavamwe
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source