Results 51 to 60 of about 32,809 (256)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Organisational justice, support and cynicism: A moderated mediation model of organisational citizenship behaviour in South African workplaces

SA Journal of Human Resource Management
Orientation: Organisational success not only demands effective employee performance but also requires discretionary contributions beyond formal job responsibilities.
Monica Kirsten
doaj   +1 more source

Ethical behaviour, organisational support and employee outcomes in driving public sector organisational performance [PDF]

RAUSP Management Journal
PurposeThis study aims to investigate the relationships between ethical behaviour, perceived organisational support (POS) and organisational performance within Nigeria’s Federal Ministry of Labour and Employment (FMLE).Design/methodology/approachThis ...
Abdulrazaq Kayode Abdulkareem, Abdulrasaq Ajadi Ishola, Zulfah Jumoke Abdulkareem, Kazeem Adebayo Oladimeji, Abdulhakeem Adejumo, Ahmad Ajibola Ayinla   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Relationship between perceived organizational support, leadership behavior, and job satisfaction: An empirical study in Iran

Intangible Capital, 2010
As the second largest producer of cement after Egypt in the Middle East, Iran planned to increase production from 33 million ton/yr (Mt/yr) currently to 70 Mt/yr by 2021 due to increase in local demand and also to compete in export markets (Dehqan, 2002).
Zainal Ariffin Ahmad, Zeinab Amini Yekta
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The influence of perceived organisation support on employees engagement in Tanzania: a case of SMEs

Pressacademia, 2023
Purpose- For the organization to strive in today's competitive environment, managers should provide a working environment that is conducive and supportive to its members/employees. Human beings like to be recognized, valued, and taken care of while they are performing their duties.
openaire   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Factors Influencing the Utilisation of High-Performance Computing (HPC) Systems in Higher Education Institutions

International Journal of Applied Research in Business and Management
Understanding how organisational support, perceived ease of use, and perceived usefulness influence the actual use of a High-Performance Computing (HPC) system sheds light on its adoption within a higher education institution.
Reginald Mulalo Ndwamai, Hlanganipai Ngirande   +1 more
doaj   +1 more source