Results 171 to 180 of about 8,582,216 (300)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Acceptability, Usability, and Perceived Quality of Care of a Digital Decision Support System in Tele-Primary Health Care in Sindh, Pakistan: Sequential Explanatory Mixed Methods Pilot Study. [PDF]

JMIR Form Res
Jawed S, Tahir HN, Shaikh A, Aziz H, Khurram SS, Aga IZ, Muzzamil M, Karim M, Kazi AM, Habib SS.   +9 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Multidimensional Analysis of Parent-Perceived Quality of Life in Children with Cerebral Palsy: A Cross-Sectional Study. [PDF]

Children (Basel)
López-Ruiz J, Giménez MJ, Castel-Sánchez M, Rico-Mena P, Mallo-López A, Salniccia F, Martín-Casas P.   +6 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Influence of energy drink consumption on perceived quality of life in young adults and adult population. [PDF]

Front Nutr
Otero-Requeijo M, Veiga-Rodeiro S, Belda-Ferri L, Villanueva-Blasco VJ.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Impact of prehabilitation on patient-perceived quality of recovery after surgery: prospective cohort study. [PDF]

BJS Open
Dana F, González-Colom R, Tena B, Capitán D, Momblan D, Campero B, García Lopez L, Ubré M, Sebio-García R, Zabalegui A, Martinez-Palli G, Hospital Clinic de Barcelona Prehabilitation Group.   +11 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Owner points of view and perceived quality of life of diabetic cats pre- and post-hypophysectomy for hypersomatotropism. [PDF]

J Vet Intern Med
Shelton E, Jepson R, Church D, Fenn J, Scudder C.   +4 more
europepmc   +1 more source