Results 101 to 110 of about 49,701 (247)
Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes*
Journal of Biological Chemistry, 2015 Background: Perforin is a critical component of immune homeostasis, responsible for clearing virally infected cells. Results: The molecular details of calcium binding by the perforin C2 domain are revealed.
H. Yagi +7 more
semanticscholar +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
[PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission
Genetics and Molecular BiologyPerforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT).
Luisa Zupin +6 more
doaj +1 more source
Perforin: an important player in immune response
Central European Journal of Immunology, 2014 Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells. Perforin is able to polymerize and form a channel in target cell membrane.
Iwona Osińska, K. Popko, U. Demkow
semanticscholar +1 more source
Diverse immunological roles of liver‐resident immune cells in liver diseases
Precision Medical Sciences, EarlyView.Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan +4 more
wiley +1 more source
Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management
Rheumatology &Autoimmunity, EarlyView.Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley +1 more source
Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives
British Journal of Pharmacology, EarlyView.A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano +5 more
wiley +1 more source
AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes
Clinical &Experimental Allergy, EarlyView.ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron +13 more
wiley +1 more source
Late‐onset hemophagocytic lymphohistiocytosis with neurological presentation
Clinical Case Reports, 2017 Key Clinical Message Missense mutations in genes involved in familial hemophagocytic lymphohistiocytosis can delay the onset of this life‐threatening disease.
Sarah Benezech +6 more
doaj +1 more source