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Combined glyphosate and chlorpyrifos-based pesticides impair innate and adaptive immune functions: an in vitro approach. [PDF]

Environ Health
Friedrich AD, Gareis DB, Ordoñez ME, Regge MV, Santilli MC, Rubinsztain MN, Gantov M, Amarilla MS, Gaillardou ME, Domaica CI, Fuertes MB, Zwirner NW.   +11 more
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Case Report: <i>FAS</i> spontaneous mutation in a familial hemophagocytic lymphohistiocytosis patient with a complex heterozygous mutation in <i>PRF1</i>. [PDF]

Front Immunol
Ding W, Li D, Yu Q, Wang Y, Zhang L.
europepmc   +1 more source

mRNA-engineered T lymphocytes secreting bispecific T cell engagers with therapeutic potential in solid tumors. [PDF]

Front Immunol
Zagorac I, Ramírez-Fernández Á, Tapia-Galisteo A, Rubio-Pérez L, Gómez-Rosel M, Grau M, Rodríguez-Peralto JL, Álvarez-Vallina L, Blanco B.   +8 more
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CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier.

Biochemical and Biophysical Research Communications - BBRC, 2019
Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin
Zhaoxiang Liu, Hua Zhang, Hong Xia, Baocheng Wang, Renwen Zhang, Qun Zeng, Lingzhi Guo, Kui Shen, Bata Wang, Y. Zhong, Zhizhong Li, Guodong Sun   +11 more
semanticscholar   +1 more source

Perforin: structure and function

Immunology Today, 1995
Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released by cytoplasmic granules. The protein is partially homologous to the terminal components of the membrane attack complex of complement and produces pores of up to 20 nm in diameter on target membranes.
C C, Liu, C M, Walsh, J D, Young
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Perforin and Lymphocyte‐mediated Cytolysis

Immunological Reviews, 1995
We have discussed in the previous sections the recent progress made toward elucidating the regulatory mechanism of perforin gene transcription and the domain structure of the perforin molecule. It appears that the expression of perforin is, at least partially, controlled at the transcription level through the interaction between killer cell-specific ...
C C, Liu, P M, Persechini, J D, Young
openaire   +2 more sources

Perforin and Human Diseases

2014
Natural killer (NK) cells and cytotoxic T lymphocytes (CTL) use a highly toxic pore-forming protein perforin (PFN) to destroy cells infected with intracellular pathogens and cells with pre-cancerous transformations. However, mutations of PFN and defects in its expression can cause an abnormal function of the immune system and difficulties in ...
Omar, Naneh, Tadej, Avčin, Apolonija, Bedina Zavec   +2 more
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Perforin-induced pore formation

Immunology Today, 1991
(1990) .1. Immunol. 144, 1196-1201 43 Podack, E.R. (1986)J. Cell. Biochem. 30, 133-1170 44 Ostergaard, H.L., Kane, K.P., Mescher, M.F. and Clark, W.R. (1987) Nature 330, 71-72 45 Trenn, G., Takayama, H. and Sitkovsky, M.V. (1987) Nature 330, 72-74 46 Berke, G., Sullivan, K.A. and Amos, D.B.
Olivier Krähenbühl, Jürg Tschopp
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Structure and function of human perforin

Nature, 1988
Perforin (P1) is a cytolytic protein with similarity to complement component C9. P1 has been described as a unique component of murine cytolytic T-cell and rat natural killer cell granules Previous studies indicated that human granules and P1 differed from murine granules and P1 in that they appeared to be cytolytically less active and lacked the ...
M G, Lichtenheld, K J, Olsen, P, Lu, D M, Lowrey, A, Hameed, H, Hengartner, E R, Podack   +6 more
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Human T regulatory cells can use the perforin pathway to cause autologous target cell death.

Immunity, 2004
Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill virally infected cells and tumor cells. Mutations in genes important for this pathway are associated with several human diseases.
W. Grossman, J. Verbsky, W. Barchet, M. Colonna, J. Atkinson, T. Ley   +5 more
semanticscholar   +1 more source