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Perforin and granzymes: function, dysfunction and human pathology
Nature Reviews Immunology, 2015Ilia Voskoboinik +2 more
exaly +2 more sources
Functional significance of the perforin/granzyme cell death pathway
Nature Reviews Immunology, 2002Mark Smyth +2 more
exaly +2 more sources
The role of perforin and granzymes in diabetes [PDF]
Cell Death and Differentiation, 2009 Type 1 diabetes results from autoimmune destruction of pancreatic beta-cells by CD8(+) T cells. The requirement for CD8(+) T cells implicates perforin and granzymes as effectors of tissue destruction. Diabetogenic cytotoxic T cells kill beta-cells by the perforin/granzyme pathway in vitro.
H E Thomas, Trapani J A
exaly +3 more sources
Biochemical and Biophysical Research Communications - BBRC, 2019
Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin
Zhaoxiang Liu +11 more
semanticscholar +1 more source
Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin
Zhaoxiang Liu +11 more
semanticscholar +1 more source
Perforin: structure and function
Immunology Today, 1995Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released by cytoplasmic granules. The protein is partially homologous to the terminal components of the membrane attack complex of complement and produces pores of up to 20 nm in diameter on target membranes.
C C, Liu, C M, Walsh, J D, Young
openaire +2 more sources
2014
Natural killer (NK) cells and cytotoxic T lymphocytes (CTL) use a highly toxic pore-forming protein perforin (PFN) to destroy cells infected with intracellular pathogens and cells with pre-cancerous transformations. However, mutations of PFN and defects in its expression can cause an abnormal function of the immune system and difficulties in ...
Omar, Naneh +2 more
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Natural killer (NK) cells and cytotoxic T lymphocytes (CTL) use a highly toxic pore-forming protein perforin (PFN) to destroy cells infected with intracellular pathogens and cells with pre-cancerous transformations. However, mutations of PFN and defects in its expression can cause an abnormal function of the immune system and difficulties in ...
Omar, Naneh +2 more
openaire +2 more sources
Structure and function of human perforin
Nature, 1988Perforin (P1) is a cytolytic protein with similarity to complement component C9. P1 has been described as a unique component of murine cytolytic T-cell and rat natural killer cell granules Previous studies indicated that human granules and P1 differed from murine granules and P1 in that they appeared to be cytolytically less active and lacked the ...
M G, Lichtenheld +6 more
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Structure and Function of Perforin
1988The most striking aspect of lymphocyte-mediated cytolysis is the formation of membrane lesions on target membranes as first described by Dourmashkin et al. (1980). In these early studies, a mixed population of effector cells was used, leaving open the question as to whether the observed membrane lesions were in fact assembled by cytotoxic lymphocytes ...
E R, Podack +3 more
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Perforin and Lymphocyte‐mediated Cytolysis
Immunological Reviews, 1995We have discussed in the previous sections the recent progress made toward elucidating the regulatory mechanism of perforin gene transcription and the domain structure of the perforin molecule. It appears that the expression of perforin is, at least partially, controlled at the transcription level through the interaction between killer cell-specific ...
C C, Liu, P M, Persechini, J D, Young
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