Results 231 to 240 of about 51,558 (279)

Cloning and characterization of the trout perforin

Fish & Shellfish Immunology, 2009
The pore-forming protein, perforin is one of the effectors of cell-mediated killing. A perforin cDNA clone was isolated from rainbow trout (Oncorhynchus mykiss) after screening of a spleen cDNA library. The full-length cDNA is 2070 bp in size, encoding for a polypeptide of 589 amino acids.
Sofia, Athanasopoulou, Dimitra, Marioli, Angeliki, Mikrou, Anastasios D, Papanastasiou, Ioannis K, Zarkadis   +4 more
openaire   +2 more sources

Addressing the mysteries of perforin function

Immunology & Cell Biology, 2006
Perforin is a cytolytic protein stored in secretory granules of CTL and NK cells. It synergizes with proapoptotic serine proteases, granzymes, to deliver the lethal hit to virus‐infected or transformed target cells. The mechanism of perforin action has not been described beyond its original characterization in the 1980s, and its role in human disease ...
Ilia, Voskoboinik, Joseph A, Trapani
openaire   +2 more sources

A Central Role of Perforin in Cytolysis?

Annual Review of Immunology, 1991
Studies on the gene structure, on the transcript, and on perforin protein are reviewed, including intracellular trafficking. Perforin transcription is tightly regulated and specific for CTL and NK. Two independent pathways for perforin induction exist, only one of them being IL-2 independent. Perforin expression in vitro and in vivo correlates with the
E R, Podack, H, Hengartner, M G, Lichtenheld   +2 more
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The distribution of perforin in normal tissues

Immunology Letters, 1991
We describe the production of monoclonal antibodies to murine and human forms of the lymphocyte pore-forming protein (perforin, PFP, or cytolysin), a major granule-localized cytolytic mediator of CTL and NK cells. Antibodies were raised against both murine perforin purified from a CTL line, and human perforin expressed in bacteria as a fusion protein ...
S V, Joag, L M, Zheng, P, Persechini, J, Michl, E, Parr, J D, Young   +5 more
openaire   +2 more sources

Human T regulatory cells can use the perforin pathway to cause autologous target cell death.

Immunity, 2004
Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill virally infected cells and tumor cells. Mutations in genes important for this pathway are associated with several human diseases.
W. Grossman, J. Verbsky, W. Barchet, M. Colonna, J. Atkinson, T. Ley   +5 more
semanticscholar   +1 more source

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Nature, 1994
D. Kägi, B. Ledermann, K. Bürki, P. Seiler, B. Odermatt, K. Olsen, E. Podack, R. Zinkernagel, H. Hengartner   +8 more
semanticscholar   +1 more source

Islet rejection in perforin-deficient mice: the role of perforin and Fas.

Transplantation, 1997
Perforin and Fas are the two main pathways by which cytotoxic T lymphocytes (CTLs) mediate target cell lysis in vitro. The perforin pathway is predominantly used by CD8+ cells, which comprise the majority of CTLs. The Fas pathway has been demonstrated to be the principal cytolytic mechanism in CD4+ CTLs.
K R, Ahmed, T B, Guo, K K, Gaal
openaire   +1 more source

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.

Science, 1994
D. Kägi, F. Vignaux, B. Ledermann, K. Bürki, V. Depraetere, S. Nagata, H. Hengartner, P. Golstein   +7 more
semanticscholar   +1 more source

Perforin: Structure, Function, and Regulation

1992
The mechanism of lymphocyte-mediated cytolysis is controversial (see recent reviews Bleackley et al. 1988; Brunet et al. 1988; Clark et al. 1988; Mueller et al. 1988; Muller-Eberhard 1988; Munger et al. 1988; Nagler-Anderson et al. 1988; Sitkovsky 1988; Young et al. 1988; Podack et al. 1988; Jenne and Tschopp 1988a, b; Bleackley 1988; Hershberger et al.
openaire   +2 more sources

Perforin

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +2 more sources