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Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease [PDF]
Frontiers in NeuroscienceIntroductionIn diabetic retinopathy, pericyte dysfunction, pericyte loss, and inner blood–retinal barrier (iBRB) dysfunction contribute to neurovascular unit (NVU) impairment.
Noëlle Bakker-van Bugnum +11 more
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MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice [PDF]
Fluids and Barriers of the CNSBackground While the role of pericytes in blood-brain barrier (BBB) disruption and neuroinflammation is well-established in adult neurological disorders, their contribution to neonatal brain injury is largely unexplored. Here, we investigated the role of
Shirley Hu +8 more
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Nature Communications, 2022 Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.
Franca Schmid +2 more
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Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity [PDF]
Advanced SciencePericytes exhibits distinct morphological features on microvessels during various stages of brain‐blood barrier (BBB) development and neurological disorders. However, the underlying mechanisms by which pericyte morphology influences BBB integrity are not
Chang‐Xiong Gong +16 more
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Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nature Communications, 2017 The angiopoietins regulate vascular maturation, angiogenesis and lymphangiogenesis via their Tie receptors that were long believed to be endothelium-specific.
Junhao Hu +2 more
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Pericyte Expression of VEGF-A Minimally Impacts Ocular Vascular Development and Neovascularization [PDF]
CellsPericytes produce vascular endothelial growth factor-A (VEGF-A; hereafter referred to as VEGF). VEGF inhibits pericyte proliferation and migration through enhanced VEGFR2 and PDGFRβ heterodimerization.
Yong-Seok Song +5 more
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In vivo Single Cell Optical Ablation of Brain Pericytes
Frontiers in Neuroscience, 2022 Pericytes have myriad functions in cerebrovascular regulation but remain understudied in the living brain. To dissect pericyte functions in vivo, prior studies have used genetic approaches to induce global pericyte loss in the rodent brain. However, this
Cara D. Nielson +7 more
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Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats [PDF]
International Journal of Ophthalmology, 2018 AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor,
Nadia Artha Dewi +4 more
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Cells, 2021 Pericytes are increasingly recognized as being important in the control of blood–brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and ...
Diana G. Bohannon +2 more
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Frontiers in Endocrinology, 2023 Diabetic retinopathy (DR) is a disease that causes visual deficiency owing to vascular leakage or abnormal angiogenesis. Pericyte apoptosis is considered one of the main causes of vascular leakage in diabetic retina, but there are few known therapeutic ...
Iljin Kim +7 more
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