Results 11 to 20 of about 22,988 (259)
Cells, 2023 Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier.
Pengfei Li, Hongkuan Fan
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Microcirculation, 2008 ABSTRACTObjectives: Cochlear pericytes are not well characterized. The aim of this study was to further advance the characterization of cochlear pericyte location and distribution, with particular focus on pericyte‐related proteins on the capillaries of the cochlear lateral wall that are functionally integral to structure, contraction, and gap junction
Xiaorui, Shi +7 more
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Pericytes: The lung-forgotten cell type
Frontiers in Physiology, 2023 Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmonary arterial hypertension (PAH) and allergic asthma due to their ability to differentiate into scar-forming ...
Annelise T. Garrison +5 more
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Nature Communications, 2020 The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown.
Tanguy Lechertier +16 more
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Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro. [PDF]
PLoS ONE, 2011 Microvascular pericytes are of key importance in neoformation of blood vessels, in stabilization of newly formed vessels as well as maintenance of angiostasis in resting tissues.
Jakob Karén +5 more
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Neurobiology of Disease, 2018 Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilepsy ...
Wendy Klement +10 more
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The Journal of Clinical Investigation, 2022 Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood.
Nils Korte +9 more
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Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications
Frontiers in Cell and Developmental Biology, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Emmanuel Nwadozi +2 more
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Metabolic Stress Impairs Pericyte Response to Optogenetic Stimulation in Pancreatic Islets
Frontiers in Endocrinology, 2022 Pancreatic islets are highly vascularized micro-organs ensuring whole body glucose homeostasis. Islet vascular cells play an integral part in sustaining adequate insulin release by beta cells.
Aurélien Michau +14 more
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Molecular Neurodegeneration, 2022 Background Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer’s disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear.
Jun Wang +10 more
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