Results 21 to 30 of about 22,988 (259)
Diabetes, 2008 OBJECTIVE— The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage. In this study, we assessed loss of pericyte subgroups and the contribution of Ang-2 to pericyte migration.
Frederick Pfister +8 more
openaire +1 more source
Pericyte mechanics and mechanobiology [PDF]
Journal of Cell Science, 2021 ABSTRACT Pericytes are mural cells of the microvasculature, recognized by their thin processes and protruding cell body. Pericytes wrap around endothelial cells and play a central role in regulating various endothelial functions, including angiogenesis and inflammation.
Claire A. Dessalles +2 more
openaire +3 more sources
Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. [PDF]
PLoS ONE, 2012 During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane.
Shijun Wang +6 more
doaj +1 more source
Frontiers in Human Neuroscience, 2022 Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they ...
Samantha Selhorst +10 more
doaj +1 more source
Calcium Signalling in Pericytes [PDF]
Journal of Vascular Research, 2014 Recent advances in pericyte research have contributed to our understanding of the physiology and pathophysiology of microvessels. The microvasculature consists of arteriolar and venular networks located upstream and downstream of the capillaries.
Theodor, Burdyga, Lyudmyla, Borysova
openaire +2 more sources
Pericytes Across the Lifetime in the Central Nervous System
Frontiers in Cellular Neuroscience, 2021 The pericyte is a perivascular cell type that encapsulates the microvasculature of the brain and spinal cord. Pericytes play a crucial role in the development and maintenance of the blood-brain barrier (BBB) and have a multitude of important functions in
Hannah C. Bennett, Yongsoo Kim
doaj +1 more source
World Journal of Nephrology, 2013 To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type (WT) and angiotensinogen deficient (AGT -/-) mice at different developmental ...
Alison C, Berg +4 more
openaire +2 more sources
Pericytes modulate endothelial sprouting [PDF]
Cardiovascular Research, 2013 Angiogenic sprouts arise from microvessels formed by endothelial cells (ECs) invested by pericytes (PCs). The aim of this study was to examine the role of PCs in angiogenic sprouting, an understudied phenomenon.We adapted a human EC spheroid model to examine PC effects on vascular endothelial growth factor-A-induced EC sprouting in vitro by using Bcl-2-
William G, Chang +4 more
openaire +2 more sources
IBRO Neuroscience ReportsAstrocytes maintain glutamate homeostasis in the central nervous system (CNS) via glutamate uptake through Na+-dependent excitatory amino acid transporters (EAAT1 and EAAT2), and this process is regulated by several CNS cell types. However, it is unclear
Kenta Sakai +6 more
doaj +1 more source
Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis
Frontiers in Aging Neuroscience, 2018 The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function.
Andrée-Anne Berthiaume +7 more
doaj +1 more source