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Perilipin 5: putting the brakes on lipolysis1
Journal of Lipid Research, 2013 openaire +1 more source
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Journal of Cell Science, 2022
ABSTRACT Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has ...
Charles P. Najt +2 more
openaire +2 more sources
ABSTRACT Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has ...
Charles P. Najt +2 more
openaire +2 more sources
Perilipin 5 Is Protective in the Ischemic Heart
International Journal of Cardiology, 2016 Myocardial ischemia is associated with alterations in cardiac metabolism, resulting in decreased fatty acid oxidation and increased lipid accumulation. Here we investigate how myocardial lipid content and dynamics affect the function of the ischemic heart, and focus on the role of the lipid droplet protein perilipin 5 (Plin5) in the pathophysiology of ...
Fred Haugen +2 more
exaly +3 more sources
Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy [PDF]
New England Journal of Medicine, 2011 Perilipin is the most abundant adipocyte-specific protein that coats lipid droplets, and it is required for optimal lipid incorporation and release from the droplet. We identified two heterozygous frameshift mutations in the perilipin gene (PLIN1) in three families with partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes ...
Guillaume Charpentier +2 more
exaly +3 more sources
Perilipin A and the control of triacylglycerol metabolism
Molecular and Cellular Biochemistry, 2008Perilipin A is the most abundant protein associated with the lipid droplets of adipocytes and functions to control both basal and stimulated lipolysis. Under basal or fed conditions, perilipin A shields stored triacylglycerols from cytosolic lipases, thus promoting triacylglycerol storage.
Dawn L, Brasaemle +4 more
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Characterization of a splice variant of perilipin 5
The FASEB Journal, 2022Lipid storage provides energy stores for the body in times of increased oxidative requirements, such as fasting or exercise, but when the balance of lipid storage and mobilization is disrupted human health suffers. Implications for increased lipid storage include risk factors for developing type II diabetes mellitus and non‐alcoholic fatty liver ...
Kaylee Vanhorenbeck, John T. Tansey
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Control of Lipolysis by Perilipins
The FASEB Journal, 2012The perilipins are a family of 5 proteins that are among the most abundant lipid droplet‐associated proteins in animal cells; most cells in the body express 2 – 4 perilipins. Perilipins form organizing scaffolds at the surfaces of lipid droplets to coordinate the activity of lipases and other factors.
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The Journal of Nutritional Biochemistry, 2015
Lipid accumulation in macrophages contributes to atherosclerosis. Within macrophages, lipids are stored in lipid droplets (LDs); perilipin-2 and perilipin-3 are the main LD-associated proteins. Postprandial triglyceride (TG)-rich lipoproteins induce LD accumulation in macrophages.
Varela, Lourdes +7 more
openaire +3 more sources
Lipid accumulation in macrophages contributes to atherosclerosis. Within macrophages, lipids are stored in lipid droplets (LDs); perilipin-2 and perilipin-3 are the main LD-associated proteins. Postprandial triglyceride (TG)-rich lipoproteins induce LD accumulation in macrophages.
Varela, Lourdes +7 more
openaire +3 more sources
Perilipin and adipophilin expression in lipid loaded macrophages
Biochemical and Biophysical Research Communications, 2007Lipid-filled macrophages (foam cells) are a defining feature of atherosclerotic plaques. Foam cells contain lipid droplet-associated proteins that in other cell types regulate lipid turnover. In foam cell such proteins may directly affect lipid droplet formation and lipid efflux.
Jenny, Persson +3 more
openaire +2 more sources