Results 91 to 100 of about 3,695 (191)

A murine model for neuropsychiatric disorders associated with group A β-hemolytic streptococcal infection [PDF]

, 2004
A syndrome of motoric and neuropsychiatric symptoms comprising various elements, including chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur in association with group A β-hemolytic streptococcal (GABHS ...
Hoffman, Kurt L., Hornig, Mady, Jabado, Omar J., Lipkin, W. Ian, Yaddanapudi, Kavitha   +4 more
core   +2 more sources

Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection

Frontiers in Integrative Neuroscience, 2022
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Previous studies demonstrated that the administration of ChABC after spinal
Masahito Takiguchi, Kanae Miyashita, Kohei Yamazaki, Kengo Funakoshi   +3 more
doaj   +1 more source

Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction. [PDF]

, 2013
Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of viral
Kovac, S, Schorge, S, Wanisch, K
core   +2 more sources

Anti‐Neuroinflammation Activity of Essential Oils and Fatty Acids

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes.
Zelong Jin, Yige Song, Ahmed Attia Ahmed Abdelmoaty, Feng Lin, Jiujun Li, Xianyang Chen   +5 more
wiley   +1 more source

Shaping Synapses by the Neural Extracellular Matrix

Frontiers in Neuroanatomy, 2018
Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a ...
Maura Ferrer-Ferrer, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev   +3 more
doaj   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall   +3 more
wiley   +1 more source

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Neural Plasticity, 2016
Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline of neural plasticity, and disruption of PNNs reactivates neural plasticity in ...
Shinji Miyata, Hiroshi Kitagawa
doaj   +1 more source

Perineuronal nets protect fast-spiking interneurons against oxidative stress [PDF]

Proceedings of the National Academy of Sciences, 2013
A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements of these fast-spiking cells may render them susceptible to redox dysregulation and oxidative stress.
Cabungcal, Jan-Harry, Steullet, Pascal, Morishita, Hirofumi, Kraftsik, Rudolf, Cuenod, Michel, Hensch, Takao, Do, Kim Q.   +6 more
openaire   +4 more sources

Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing

Clinical Endocrinology, Volume 104, Issue 1, Page 67-74, January 2026.
ABSTRACT Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling and malignancy aggressiveness. Design We conducted a retrospective multicenter study involving patients with
Idit Tessler, Grégoire B. Morand, Nir A. Gecel, Arad Dotan, Tzahi Yamin, Eran E. Alon, Richard J. Payne, Galit Avior   +7 more
wiley   +1 more source