Results 111 to 120 of about 3,695 (191)
Ibrain, Volume 11, Issue 4, Page 403-421, Winter 2025.Synaptic adhesion molecules (SAM) are essential for the formation, maturation, function, plasticity, and assembly of synaptic connections, all critical for normal neurodevelopment. Excessive exposure to neurotoxic metals during development could disrupt the developing brain and potentially lead to neurodevelopmental disorders (NDDs).
Toheeb O. Oyerinde +7 more
wiley +1 more source
JOR SPINE, Volume 8, Issue 4, December 2025.Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley +1 more source
Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
BMC Neuroscience, 2018 Background Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present.
Hiroshi Ueno +8 more
doaj +1 more source
Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2 [PDF]
, 2017 Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) chain. In cartilage, CS plays important roles as the main component of the extracellular matrix (ECM), existing as side chains of the major cartilage proteoglycan, aggrecan.
Fuseya Sayaka +16 more
core +2 more sources
Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations
MedComm – Oncology, Volume 4, Issue 4, December 2025.Breast cancer brain metastasis (BCBrM) is driven by a multistep metastatic cascade and shaped by dynamic tumor–brain interactions. This review integrates current mechanistic insights, from molecular signaling pathways to immune evasion, and evaluates preclinical models and emerging therapies.
Jing Feng +3 more
wiley +1 more source
Extracellular matrix of the central nervous system: from neglect to challenge [PDF]
, 2018 The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal ...
Dours-Zimmermann, María +1 more
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Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury [PDF]
, 2018 Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies.
Albin +46 more
core +2 more sources
Scientific Reports, 2017 The purpose of this study is to conduct modeling and simulation to understand the effect of shock-induced mechanical loading, in the form of cavitation bubble collapse, on damage to the brain’s perineuronal nets (PNNs).
Yuan-Ting Wu, Ashfaq Adnan
doaj +1 more source
Networks of blood proteins in the neuroimmunology of schizophrenia. [PDF]
, 2018 Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be prognostic.
Addington, J. +17 more
core +2 more sources
Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia [PDF]
, 2017 Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention ...
Cuenod, Michel +2 more
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