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Loss of Perineuronal Net in ME7 Prion Disease [PDF]
Journal of Neuropathology and Experimental Neurology, 2008 Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Samar Betmouni
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The two faces of perineuronal nets
NeuroReport, 2000Perineuronal nets are extracellular structures enwrapping the soma and proximal dendrites of some neurons known to be parvalbumin immunoreactive. The composition of the nets is not completely known, but it can change between different neurons. We studied the heterogeneous composition of a specific component of perineuronal nets, the signaling molecule ...
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Perineuronal nets’ role in metabolism
American Journal of Physiology-Endocrinology and MetabolismPerineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies.
Nan Zhang +6 more
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The perineuronal net and the control of CNS plasticity
Cell and Tissue Research, 2012Perineuronal nets (PNNs) are reticular structures that surround the cell body of many neurones, and extend along their dendrites. They are considered to be a specialized extracellular matrix in the central nervous system (CNS). PNN formation is first detected relatively late in development, as the mature synaptic circuitry of the CNS is established and
Difei, Wang, James, Fawcett
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Journal fur Hirnforschung, 1983
Perineuronal nets could be visualized with some Golgi methods in the rat's brain. Nets were seen in telencephalic, diencephalic and mesencephalic structures covering somata and proximal dendrites of different neuronal types. Some nets could be found originating from microglia cells. In most cases their origin is not recognizable.
K, Brauer, L, Werner, L, Leibnitz
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Perineuronal nets could be visualized with some Golgi methods in the rat's brain. Nets were seen in telencephalic, diencephalic and mesencephalic structures covering somata and proximal dendrites of different neuronal types. Some nets could be found originating from microglia cells. In most cases their origin is not recognizable.
K, Brauer, L, Werner, L, Leibnitz
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Characterization of Perineuronal Nets in the Human Cerebellum
The CerebellumPerineuronal nets (PNNs) are condensed extracellular matrix structures that regulate synaptic plasticity and neuronal stability. While their distribution and function have been well characterized in rodents, PNNs remain largely understudied in the human cerebellum.
Refilwe, Mpai +9 more
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Perineuronal net expression in the brain of a hibernating mammal
Brain Structure and Function, 2019During hibernation, mammals like the 13-lined ground squirrel cycle between physiological extremes. Most of the hibernation season is spent in bouts of torpor, where body temperature, heart rate, and cerebral blood flow are all very low. However, the ground squirrels periodically enter into interbout arousals (IBAs), where physiological parameters ...
Anna, Marchand, Christine, Schwartz
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Extracellular matrix and perineuronal nets in CNS repair
Developmental Neurobiology, 2011AbstractA perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in sub‐populations of neurons in the central nervous system (CNS). First reported by Camillo Golgimore than a century ago, the molecular structure and the potential role of this matrix have
Jessica C F, Kwok +3 more
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Perineuronal Nets Protect Fear Memories from Erasure
Science, 2009Adult Fears Why are fear memories almost impossible to get rid of—even with extensive extinction training? Animal studies have shown that the efficacy of extinction learning depends on age. Fear memories in young animals can be permanently erased, but in adults they can be easily recovered after extinction ...
Gogolla, N. +3 more
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Distribution of perineuronal nets in the adult rat neocortex
Somatosensory & Motor ResearchPerineuronal nets (PNNs) are specialised extracellular matrix structures of the central nervous system that predominantly surround inhibitory interneurons. The development of PNNs is activity dependent and relies on sensory input to mature to an adult expression pattern, coinciding with the crysallization of synaptic circuitry following the closure of ...
Kumarie Budhu +4 more
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