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Perineuronal Nets: From Structure to Neurological Disorders

Current Medicinal Chemistry
Perineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI).
Xianghe, Li   +5 more
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Perineuronal Nets in the Superior Olivary Complex

2018
Abstract This chapter addresses perineuronal nets in the superior olivary complex, a collection of nuclei in the auditory brainstem that are involved in the processing of sound source location. Perineuronal nets, a specific form of extracellular matrix, are believed to control synaptic plasticity.
Markus Morawski, Mandy Sonntag
openaire   +1 more source

An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity

International Journal of Molecular Sciences, 2021
Daniela Carulli, Joost Verhaagen
exaly  

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

Neuron, 2017
Emilia Favuzzi   +2 more
exaly  

Normal Development of the Perineuronal Net in Humans; In Patients with and without Epilepsy

Neuroscience, 2018
Stephanie L Rogers   +2 more
exaly  

Perineuronal Nets in the Pathophysiology of Alzheimer's Disease

Alzheimer’s disease (AD) affects approximately 55 million individuals globally and is the most prevalent form of dementia, characterized by profound impairments in memory and cognition that extend beyond normal aging. AD is a progressive neurodegenerative disorder in which subtle molecular and cellular alterations occur decades before the clinical ...
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