Results 81 to 90 of about 3,695 (191)

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Neural Plasticity, 2016
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
F. de Winter, J. C. F. Kwok, J. W. Fawcett, T. T. Vo, D. Carulli, J. Verhaagen   +5 more
doaj   +1 more source

Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline [PDF]

, 2017
Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance.
BA Sorg, C Grillon, C Idzikowski, CC Chi, D Schiller, DR Bach, DR Bach, DR Bach, DR Bach, DR Bach, E Ahler, E Knapska, EA Antoniadis, ET Walters, F Faul, GD Gale, GW Huntley, IA Chatzispyrou, J Li, J Pinheiro, JE LeDoux, JM Pearce, JS Brown, K Nader, KW Spence, L Laux, LM Golub, M Davis, M Dziembowska, M Gawlak, M Hautzinger, M Karlsson, M Kindt, M Slaker, M Soeter, M Staib, Marijn C. W. Kroes, MJ Hylin, N Gogolla, PC Meighan, R Hanemaaijer, R Sjouwerman, RY Tsien, S Khemka, S Zhang, T Gorkiewicz, TE Brown, V Nagy, V Nagy, W Boucsein, WA Falls, WK Kirchner, XB Wang   +52 more
core   +2 more sources

Glucagon‐Like Peptide‐1 Targets in the Human Nodose Ganglion

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Our findings demonstrate that the human nodose ganglion expresses Glp1r mRNA and reveal species similarities and differences in Glp1r expression between humans and mice. ABSTRACT Given the rapidly expanding clinical use of glucagon‐like peptide‐1 receptor (GLP1R) agonists—well‐known for their antidiabetic and antiobesity effects—it is increasingly ...
Warda Merchant, Claire Mackaaij, Cindy G. J. Cleypool, Laurent Gautron   +3 more
wiley   +1 more source

Muscarinic receptor-dependent long term depression in the perirhinal cortex and recognition memory are impaired in the rTg4510 mouse model of tauopathy. [PDF]

, 2018
This is the final version of the article. Available from the publisher via the DOI in this record.Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer's disease and fronto-temporal dementia, are often associated impairments in ...
Barker, GRI, Brown, JT, Randall, AD, Scullion, SE, Warburton, EC   +4 more
core   +3 more sources

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]

The Journal of Neuroscience, 2016
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A, Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica CF, Miquel, Marta   +6 more
openaire   +6 more sources

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, Volume 293, Issue 3, Page 766-780, February 2026.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +5 more sources

Perineuronal nets in brain physiology and disease

Seminars in Cell & Developmental Biology, 2019
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory.
Damien Testa, Alain Prochiantz, Ariel A. Di Nardo   +2 more
openaire   +3 more sources

Combined Neuroprotective Effects of N,N‐Dimethyltryptamine and Ventral Root Reimplantation Following Spinal Root Avulsion in Rats

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
The ventral root avulsion (VRA) model provides an excellent experimental paradigm for studying injuries at the Central/Peripheral Nervous Systems (CNS/PNS) interface. By physically disconnecting motoneurons (MNs) from the spinal cord surface, VRA induces profound cellular, molecular, and functional deficits with limited spontaneous recovery.
Paola Andrea Caro Aponte, Edison Huertas Montoya, Italo O. Mazali, Alessandra Sussulini, Benedito Barraviera, Rui Seabra Ferreira Jr., Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +7 more
wiley   +1 more source

Cortical Layer‐Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder

Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Tamsin Karas, Asheeta A. Prasad
wiley   +1 more source