Results 11 to 20 of about 1,400 (132)

Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus). [PDF]

J Comp Neurol
The neural mechanisms underlying behavioral sensitization to pups in adult virgin California mice are poorly understood. Here, we show that pup exposure alters perineuronal net (PNN) expression in the infralimbic medial prefrontal cortex of virgin male, but not female, California mice.
Acosta MC, Warren ID, Saltzman W, Razak KA.   +3 more
europepmc   +2 more sources

The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix. [PDF]

J Neurosci Res
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Gomez A, Tran UT, Grozdanov PN, Cornwall GA.   +3 more
europepmc   +2 more sources

Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Loss of social cognition memory impairs Alzheimer's disease (AD) patients to recognize family members, friends, and caregivers. We investigate the role of perineuronal nets (PNNs), specialized coats of extracellular matrix around hippocampal CA2 neurons in AD‐associated social memory impairments.
Chaunsali L, Li J, Fleischel E, Prim CE, Kasprzak I, Jiang S, Hou S, Escalante M, Cope EC, Olsen ML, Tewari BP, Sontheimer H.   +11 more
europepmc   +2 more sources

Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats. [PDF]

Eur J Neurosci
Coordinated postnatal emergence of CRH‐ergic innervation (red) and perineuronal nets (green) in spinal micturition centers (blue) defines a sexually dimorphic timeline of circuit stabilization, highlighting a critical period for hormonally regulated visceromotor maturation (see manuscript). ABSTRACT Pelvic visceromotor functions such as micturition are
Nitabara A, Banjo Y, Takiguchi M, Funakoshi K.   +3 more
europepmc   +2 more sources

Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus. [PDF]

Epilepsia
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
Woo AM, Fleischel EJ, Patel DC, Sontheimer H.   +3 more
europepmc   +2 more sources

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]

, 2017
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert, Friedman, Alon, Gu, Feng, Heinemann, Uwe, KAUFER, daniela, Kim, Soo, Lippmann, Kristina, Milikovsky, Dan, Morrissey, Christapher, Parada, Isabel, Prince, David, Senatorov, Vladimir, Vazquez, Oscar   +12 more
core   +5 more sources

Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice. [PDF]

Aging Cell
Targeting CA2 perineuronal nets restores social/non‐social recognition memory and theta oscillations in aged mice: Aged mice displayed deficits in both social and object recognition memory, which were accompanied by enhanced perineuronal nets (PNNs) density and reduced theta power in the dCA2 region.
Mehak SF, Shivakumar AB, Jijimon F, Gupta A, Pillai VG, Gangadharan G.   +5 more
europepmc   +2 more sources

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Aganov, Albert, Arnst, Nikita, Dvoeglazova, Anastasia, Fedosimova, Svetlana, Kiyasov, Andrei, Kochneva, Anastasia, Lipachev, Nikita, Mavlikeev, Mikhail, Melnikova, Anastasia, Osin, Yuri, Paveliev, Mikhail, Shaikhutdinov, Nurislam, Titova, Angelina   +12 more
core   +1 more source

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Parasites & Vectors, 2022
Toxoplasma gondii is able to manipulate the host immune system to establish a persistent and efficient infection, contributing to the development of brain abnormalities with behavioral repercussions.
Ramayana Morais de Medeiros Brito, Ywlliane da Silva Rodrigues Meurer, Jully Anne Lemos Batista, Andréa Lima de Sá, Cássio Ricardo de Medeiros Souza, Janeusa Trindade de Souto, Valter Ferreira de Andrade-Neto   +6 more
doaj   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source