Results 41 to 50 of about 1,400 (132)

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]

, 2016
Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK
Filice, Federica, Schwaller, Beat, Sungur, Ayse Özge, Vörckel, Karl Jakob, Wöhr, Markus   +4 more
core   +1 more source

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? [PDF]

, 2016
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to abnormal neurodevelopmental trajectories, affecting local neuronal networks and ...
A. Monin, Abekawa, Atallah, Atkuri, Avshalumov, Back, Baker, Ballesteros, Bartos, Baud, Behrens, Behrens, Belforte, Bentsen, Berk, Berk, Beurdeley, Bilbo, Bodhinathan, Brenhouse, Bridges, Brown, Buckholtz, Buelna-Chontal, Bulut, Byne, Cabungcal, Cabungcal, Cabungcal, Cadet, Cai, Callahan, Cao, Cardin, Carlen, Carlson, Carmeli, Cavaliere, Chattopadhyaya, Chew, Choi, Clay, Cleland, Corcoba, Coyle, Cyr, D. Dwir, Dalmau, das Neves Duarte, Davis, Dell'Anna, Dickerson, Dityatev, Do, Do, Do, Do, Donato, Eluvathingal, Fan, Fan, Fan, Farokhnia, Farr, Fazzari, Fitzsimmons, Fournier, Fragoso, French, Fries, Fromer, Fuchs, Fukuda, Gandal, Garate, Gawryluk, Gokhale, Goldshmit, Gravina, Gulyas, Gysin, Gysin, Hakak, Hardingham, Harris, Harris, Harte, Hikida, Hof, Hoftman, Homayoun, Huang, Hwang, Ibi, Insel, J.H. Cabungcal, Jana, Javitt, Jenkins, Jiang, Jiang, Johnson, Jones, K.Q. Do, Kann, Kantrowitz, Katsel, Kaur, Kerns, Kettenmann, Kinney, Kirov, Kocsis, Koga, Kohr, Komitova, Korotkova, Krishnan, Krystal, Kulak, Kulak, Kyriakopoulos, Lante, Lataster, Lataster, Lavoie, Lavoie, Lazarewicz, Lewis, Leza, Li, Li, Lisman, Liu, Lodge, Lodge, Lucas, Lutgen, M. Cuenod, Makinodan, Makinodan, Mandal, Martins-de-Souza, Massi, Mauney, McGee, McNally, Mehta, Meiser, Meyer, Meyer, Meyer, Miyata, Mizrahi, Moller, Monin, Morishita, Morishita, Muller, Muller, Mustafa, Myin-Germeys, Myin-Germeys, O'Donnell, O'Donnell, Oorschot, Otte, P. O'Donnell, P. Steullet, Paintlia, Pantazopoulos, Papadia, Park, Patz, Penschuck, Pinteaux, Pitts, Poels, Potvin, Powell, Purcell, Rabinovic, Ray, Reddy, Robinson, Rodriguez-Santiago, Rotaru, Rouhinen, Roux, Saetre, Schiavone, Shirai, Sinn, Smith, Smyth, Sohal, Song, Stefansson, Steiner, Steullet, Steullet, Steullet, Steullet, Stevens, Stojkovic, Sullivan, Takahashi, Takao, Timms, Tkachev, Tosic, Tseng, Tseng, Uhlhaas, Uhlhaas, Umbricht, Uranova, Uranova, Uranova, Valko, van Berckel, Vinson, Walter, Wang, Wang, Wang, Wang, Wang, Wen, Whitford, Wulff, Yanagi, Yao, Yao, Zafarullah, Zhang, Zhang, Zhang   +237 more
core   +1 more source

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +5 more sources

Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]

, 2016
S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr, Fred Colbourne, Glen Baker, Gustavo Tenorio, Ian Winship, Jayalakshmi Caliaperumal, Jee Su Suh, John W. Paylor, Liam E. Potter   +8 more
core   +4 more sources

A Role for Matrix Metalloproteases in Antidepressant Efficacy

Frontiers in Molecular Neuroscience, 2019
Major depressive disorder is a debilitating condition that affects approximately 15% of the United States population. Though the neurophysiological mechanisms that underlie this disorder are not completely understood, both human and rodent studies ...
Seham Alaiyed, Katherine Conant
doaj   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Journal of Integrative Neuroscience
Background: The perineuronal net (PNN) is an important extracellular environment around parvalbumin interneuron (PV IN) in the spinal cord.
Bowen Chen, Rong Hu, Xingying Wu, Mengting Shi, Yi Chen, Jieqi Zhang, Yi Huang, Xihan Ying, Dexiong Han, Ruijie Ma   +9 more
doaj   +1 more source

Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related circuits in the cortex and striatum of mice [PDF]

, 2016
Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication and repetitive or stereotyped patterns of behavior ...
Filice, Federica, Lauber, Emanuel, Schwaller, Beat   +2 more
core   +1 more source

Cortical Layer‐Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder

Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Tamsin Karas, Asheeta A. Prasad
wiley   +1 more source

Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke [PDF]

, 2023
Background Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechanisms.
Dzyubenko, Egor, Hermann, Dirk M., Labus, Patrick, Sardari, Maryam, Schmermund, Ben, Tokmak, Erdin, Willig, Katrin, Yin, Dongpei   +7 more
core   +2 more sources