Results 51 to 60 of about 1,400 (132)
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
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Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications [PDF]
, 2016 Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adam Davis +4 more
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Age Impacts Perineuronal Net Density in the Somatosensory Genital Cortex Independently of Gonadal Steroid Hormones [PDF]
, 2023 A hallmark of pubertal development is the rise in gonadal hormone secretions and the subsequent onset of sexual behavior. The size of the somatosensory genital cortex increases in response to both this rise in gonadal steroid hormones and sexual ...
Warren, Ian D
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The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord [PDF]
, 2022 Rather than being a stable scaffold, perineuronal nets (PNNs) are a dynamic and specialized extracellular matrix involved in plasticity modulation. They have been extensively studied in the brain and associated with neuroprotection, ionic buffering, and ...
Lane, Michael A. +2 more
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The critical role of extracellular matrix in Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
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Cell therapy for spinal cord injury with Olfactory Ensheathing Glia Cells (OECs) [PDF]
, 2018 This is the peer reviewed version of the following article: Gómez RM, Sánchez MY, Portela-Lomba M, et al. Cell therapy for spinal cord injury with olfactoryensheathing glia cells (OECs). Glia. 2018;00:1–35 which has been published in final form at GLIA
Barreto, George E. +6 more
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BDNF and JNK-signalling modulate cortical interneuron and perineuronal net development: implications for schizophrenia-linked 16p11.2 duplication syndrome [PDF]
, 2020 Schizophrenia is a neurodevelopmental disorder caused by the interaction of genetic and environmental risk factors. One of the strongest genetic risk variants is duplication of chr.16p11.2. Schizophrenia is characterised by cortical GABAergic interneuron
Morris, Brian J +2 more
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Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Lata Chaunsali
wiley +1 more source
Frontiers in NeuroscienceMaturation of the forebrain involves transitions from higher to lower levels of synaptic plasticity. The timecourse of these changes likely differs between regions, with the stabilization of some networks scaffolding the development of others.
B. Maximiliano Garduño +9 more
doaj +1 more source
JOR SPINE, Volume 8, Issue 4, December 2025.Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley +1 more source