Results 61 to 70 of about 1,400 (132)

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. [PDF]

, 2016
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS.
Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica CF, Miquel, Marta, Sorg, Barbara A   +6 more
core   +5 more sources

Environmental Enrichment Suppresses Food Seeking and Increases Inhibitory Interneuron Excitability While Decreasing Corticothalamic Neuronal Recruitment in the Prelimbic Cortex

European Journal of Neuroscience, Volume 62, Issue 10, November 2025.
Environmental enrichment (EE) reduces cue‐evoked sucrose seeking and is accompanied by enhanced inhibitory interneuron excitability and suppressed corticothalamic recruitment in the prelimbic cortex. Using brain slice electrophysiology, retrograde tracing and Fos assays, we show that EE increases baseline excitability of interneurons but not pyramidal ...
Kate Z. Peters, Romarua Agbude, Oliver G. Steele, Nobuyoshi Suto, Eisuke Koya   +4 more
wiley   +1 more source

Manipulating the Perineuronal Net in the Deep Cerebellar Nucleus [PDF]

, 2021
Perineuronal nets (PNN) are a type of specialized extracellular matrix in the central nervous system. The PNN forms during postnatal development but the ontogeny of the PNN has yet to be elucidated.
O\u27Dell, Deidre E.
core   +1 more source

Characterization of Perineuronal Nets (PNNs) in the Paraventricular Nucleus of the Hypothalamus (PVN) and their alteration in neurogenic hypertension

Abstract Perineuronal nets (PNNs) are key regulators of neuronal excitability, yet whether they are altered during neurogenic hypertension is unknown. Here, we mapped the developmental trajectory of PNNs in the paraventricular nucleus of the hypothalamus (PVN), a crucial nucleus involved in blood pressure regulation, and examined their ...
Blanco, Ismary, Chen, Sichu, Yeo, Erin, Reasonover, Samantha, Santisteban, Monica M.   +4 more
openaire   +1 more source

Developmental disruption of perineuronal nets in the medial prefrontal cortex after maternal immune activation [PDF]

, 2016
© The Author(s) 2016. Maternal infection during pregnancy increases the risk of offspring developing schizophrenia later in life. Similarly, animal models of maternal immune activation (MIA) induce behavioural and anatomical disturbances consistent with ...
A Faissner, A Klausmeyer, AA Curley, AE Takesian, AR Wolff, AR Wolff, AS Brown, AS Brown, BK Bitanihirwe, C Basar-Eroglu, CJ Machado, CL Beasley, CV Vorhees, CY Pietersen, D Bavelier, D Ibi, D Nakayama, D Wang, DA Lewis, DD Dickerson, DD Dickerson, DW Volk, E Domenici, F Passetti, G Brückner, G Brückner, G Buzsáki, G Gonzalez-Burgos, G Gonzalez-Burgos, G Koppe, H Pantazopoulos, H Pantazopoulos, H Pantazopoulos, H Yamamori, J Richetto, J Zahrt, JF Enwright, JG Howland, JJ Tukker, JR Glausier, K Fox, KE Rhodes, KM Spencer, LA Miner, M Sur, N Berardi, N Gogolla, N Mellios, NV Malkova, PE Gottschall, RY Cho, S Berretta, S Canetta, S Devanarayanan, S Giovanoli, S Hockfield, S Sangha, S Smolders, S Wiese, SA Ballendine, SA Mauney,, SJ Fung, SN Cassella, T Hashimoto, T Pizzorusso, T Reinert, U Meyer, U Meyer, U Meyer, VS Sohal, W Härtig, W Härtig, WW Eaton, WY Li, Y Piontkewitz, Y Zhang   +75 more
core   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, Volume 66, Issue 10, Page 3621-3641, October 2025.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia [PDF]

, 2017
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention ...
Cuenod, Michel, Do, Kim Q., Hensch, Takao K.   +2 more
core  

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, Volume 66, Issue 10, Page 4053-4065, October 2025.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration [PDF]

, 2017
Chondroitin sulfate proteoglycans (CSPGs) are the main active component of perineuronal nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with chondroitinase ABC or transgenic attenuation of PNNs leads to prolongation of object recognition ...
Alves, João Nuno, Bussey, Timothy, Fawcett, James W, Hilton, Sam, Kitagawa, Hiroshi, Kwok, Jessica CF, Matthews, Russell T, Saksida, Lisa M, Spillantini, Maria Grazia, Yang, Sujeong   +9 more
core   +2 more sources

Long‐Term Memory Engrams From Development to Adulthood

Hippocampus, Volume 35, Issue 5, September 2025.
ABSTRACT Memories formed in adulthood can last a lifetime, whereas those formed early in life are rapidly forgotten through a process known as infantile amnesia. In recent years, tremendous progress has been made in understanding the memory engram—the physical trace of a memory in the brain—and how it transforms as memories evolve from recent to remote.
Abigail L. Yu, Laura A. DeNardo
wiley   +1 more source