Results 161 to 170 of about 45,110 (263)

Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival. [PDF]

Nat Commun
Chen Y, Kunjamma RB, Lin K, Kai L, Dima M, Bruce K, Steckler I, Che YH, Chan-Zervas J, Eugenin von Bernhardi J, Connelly C, Ece S, Newell G, Bergles DE, Sidrauski C, Popko B.   +15 more
europepmc   +1 more source

Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a complex syndrome marked by weight loss and muscle wasting, significantly impacting patient quality of life and survival. Mechanistically, it is characterized by suppressed protein synthesis and enhanced muscle catabolism, with the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR ...
Yusaku Kaneko, Tomohiro Hino, Shunta Taminishi, Yayoi Matoba, Daisuke Motooka, Atsushi Hoshino, Satoaki Matoba   +6 more
wiley   +1 more source

Metformin triggers apoptosis via endoplasmic reticulum stress in HER2-positive breast cancer cell lines. [PDF]

Exp Ther Med
Çakmak E, Bilgici B.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

ER stress sensors at the ER-mitochondrial interface, controlling mitochondrial health in neurodegenerative diseases. [PDF]

Front Neurosci
Kunja C, Kumar V, Kodam P, Gopu CD, Maity S.   +4 more
europepmc   +1 more source

Dynamics of Fiscal Habits and Soft Budgets in Federations

Journal of Public Economic Theory, Volume 28, Issue 2, April 2026.
ABSTRACT In this paper, we are motivated by empirical evidence of persistent, implicit or explicit, bailouts in federations from high‐tier (e.g., center) governments to low‐tier (e.g., state) governments. We build a novel dynamic model for a federation containing N ≥ 2 $N\ge 2$ identical regional governments and a central government.
João Ricardo Faria, Emilson C. D. Silva
wiley   +1 more source

PERK-eIF2α activation by avian reticuloendotheliosis virus: a dual strategy to suppress apoptosis and aggravate immunosuppression for enhanced replication. [PDF]

Poult Sci
Wang Y, Xing Y, Cheng Z, Xu W, Li C, Wang G.   +5 more
europepmc   +1 more source

Weight Loss During Obesity Provokes Asparaginase‐Associated Liver Steatosis and Endoplasmic Reticulum Stress

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Lean mice and DIO mice were fed either a low‐fat maintenance diet (MD) or a high‐fat obesogenic diet (OD) during pegylated asparaginase exposure. OD exacerbated asparaginase‐induced weight loss and modestly increased liver triglycerides and ER stress in lean mice.
Chintan T. Bhavsar, Brian A. Zalma, Keigo Tomoo, Yi Zhang, Esther M. Lopez, Emily T. Mirek, Joseph L. Dixon, Gregory C. Henderson, Ronald C. Wek, Tracy G. Anthony   +9 more
wiley   +1 more source

ERS-PERK Pathway is Involved in the Repair of the Pulpo-Dentinal Complex Under an Inflammatory Microenvironment. [PDF]

Stem Cells Int
Yang Y, Li H, Miao Y, Luo Z, Niu L, Liu R.   +5 more
europepmc   +1 more source