Results 71 to 80 of about 45,110 (263)

Inadequate Zinc Intake in Adolescents Aggravates Inflammatory Bowel Disease by Inhibiting Antibody Class Switch Recombination in Mucosal B Cells Through Intestinal Microbial‐Derived KMV

iMetaMed, EarlyView.
The study reveals that inadequate zinc intake disrupts gut microbiota's ability to degrade isoleucine, leading to the accumulation of metabolite KMV. KMV inhibits antibody class‐switching in mucosal B cells by suppressing the p‐ATM‐CTIP‐Hmces pathway, impairing IgA/IgG production.
Wenbo Jiang, Yiding Geng, Bai Li, Conghui Qiao, Zijie Liu, Xinyu Shan, Xinyang Wang, Wei Wei, Tianshu Han   +8 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Ch‐Ch‐Ch‐Ch‐Changes: The Impact of Supply Base Growth, Contraction, and Turnover on Firm Innovation

Journal of Operations Management, EarlyView.
ABSTRACT Modern supply chains are experiencing more disturbances due to regulatory shifts, rising sustainability standards, emerging or declining markets, and disruption to critical inputs. Some firms react by strengthening existing supplier partnerships to resist changes, while others reconfigure relationships with suppliers to embrace changes ...
Jordan M. Barker, Ellie C. Falcone, Yang Sophie Yang‐Sun, Tingting Yan   +3 more
wiley   +1 more source

Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation.

PLoS ONE, 2007
Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2alpha. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth ...
Sharon J Sequeira, Aparna C Ranganathan, Alejandro P Adam, Bibiana V Iglesias, Eduardo F Farias, Julio A Aguirre-Ghiso   +5 more
doaj   +1 more source

Exploration and Practice of Hefei Botanical Garden in Biodiversity Conservation, Resource Utilization, and Public Education

Biological Diversity, EarlyView.
Jimei Zhang, Xu Li, Yuhua Ma, Fasih Ullah Haider, Yunfeng Zhou   +4 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.

PLoS ONE, 2009
BackgroundPERK eIF2alpha kinase is required for the proliferation of the insulin-secreting beta- cells as well as insulin synthesis and secretion. In addition, PERK signaling has been found to be an important factor in determining growth and angiogenesis
Sounak Gupta, Barbara McGrath, Douglas R Cavener   +2 more
doaj   +1 more source

Some love them, others hate them: Understanding farmers' tree planting decisions in Scotland

People and Nature, EarlyView.
Abstract Agroforestry is increasingly recognized as a sustainable agricultural land use system with potential to sequester carbon, create and repair habitats, enhance biodiversity and offer environmental and socio‐economic benefits, including improved agricultural productivity.
Albert Mvula, Katrin Prager, Josie Geris
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases

Phytotherapy Research, EarlyView.
EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun, Yonghan Pan, Ning Yang, Bing Kang, Hong Xiao, Xianglong Tang, Taiping Li, Mengjie Zhao   +7 more
wiley   +1 more source