Results 111 to 120 of about 32,727 (216)

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science
The absence of a universal reducing agent distinguishes the Prx6‐type subfamily of peroxiredoxins from the structurally similar Prx1‐type subfamily. A likely explanation for the lack of reactivity of Prx6‐type enzymes with common reducing agents is that ...
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
doaj   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, Volume 66, Issue 7, Page 1299-1315, July 2026.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, Volume 111, Issue 7, Page 3179-3190, 1 July 2026.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Mechanisms and integrative machine learning approaches to blood–brain barrier biomarker profiling for personalized ischemic stroke management

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Ischemic stroke remains a leading cause of death and disability worldwide, with blood–brain barrier (BBB) disruption playing a central role in vasogenic edema, neuroinflammation, hemorrhagic transformation, and secondary neuronal injury. The BBB is a specialized neurovascular unit composed of endothelial tight junctions, pericytes, astrocytes,
John Nzobokela, Lweendo Muchaili, Joy Kaluba Mangimela, Annet Kirabo, Sepiso K. Masenga   +4 more
wiley   +1 more source

Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles That Promote Angiogenesis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles that Promote Angiogenesis. The results from this study suggest that EVs isolated from blood immediately after the last bout of endurance exercise training (ExerV) are enriched in antioxidants. ExerVs stimulate vascular growth both in vitro and in 
Alexander M. Fliflet, Ray A. Spradlin, Yanqi Tan, Ane Nishitha Vijayan, Sung Jun Choi, Wei‐Chun Kao, Edita Aksamitiene, Michael Nelappana, Shengzhe Ding, Kai‐Yu Huang, Aryaman Joshi, Nurila Kambar, Tom Bludgen, Madeleine Meehan, Jayna L. Boss, Michael Knipp, Hongming Fan, Cecilia Leal, Roger A. Sunde, Lawrence W. Dobrucki, Stephen A. Boppart, Hyun Joon Kong, Jonathan V. Sweedler, Marni D. Boppart   +23 more
wiley   +1 more source

Fancy a gene? A surprisingly complex evolutionary history of peroxiredoxins.

Microbial Cell, 2015
Alena Zíková, Miroslav Oborník, Julius Lukeš   +2 more
doaj   +1 more source

Serum Peroxiredoxin 6 Levels and Clinical Outcomes After Acute Intracerebral Hemorrhage in Elderly Patients: A Multicenter Observational Analytical Study. [PDF]

Clin Interv Aging
Lu T, Zheng B, Wang D, Liao W, Su C, Wu X, Zhong X, Chen X, Ying G, Cai Y, Du Q, Dong X.   +11 more
europepmc   +1 more source

Investigation of viscerotropism-associated genes in <i>Leishmania tropica</i> strains causing visceral leishmaniasis. [PDF]

Front Microbiol
Ozbilgin A, Vardarlı AT, Cavus I, Dinc M, Tunali V, Beyaz M, Kose S, Yalcin T, Gündüz C.   +8 more
europepmc   +1 more source

Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins. [PDF]

Nat Chem Biol
Zimmermann J, Lang L, Malo Pueyo J, Riedel M, Wahni K, Stobbe D, Leiskau L, Aref E, Lux C, Janvier S, Vertommen D, Lenhard S, Hannemann F, Thangamuragan S, Castro H, Helms V, Tomas AM, Herrmann JM, Salvador A, Mühlhaus T, Riemer J, Messens J, Deponte M, Morgan B.   +23 more
europepmc   +1 more source