Results 31 to 40 of about 33,744 (220)
The Role of Thioredoxin/Peroxiredoxin in the β-Cell Defense Against Oxidative Damage
Frontiers in Endocrinology, 2021 Oxidative stress is hypothesized to play a role in pancreatic β-cell damage, potentially contributing to β-cell dysfunction and death in both type 1 and type 2 diabetes.
Jennifer S. Stancill, John A. Corbett
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Antioxidants, 2019 Reactive oxygen and nitrogen species have cell signaling properties and are involved in a multitude of processes beyond redox homeostasis. The peroxiredoxin (Prdx) proteins are highly sensitive intracellular peroxidases that can coordinate cell signaling
John J. Skoko +2 more
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Antiviral Function of NKEF against VHSV in Rainbow Trout
Biology, 2021 Natural killer enhancing factor (NKEF) belongs to the peroxiredoxin family of proteins, a group of antioxidants that has been extensively studied in mammals. Recently, we identified NKEF in the immunoprecipitated proteome of rainbow trout red blood cells
Veronica Chico +6 more
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Peroxiredoxins and their expression in ependymomas
Journal of Clinical Pathology, 2012 AimsPeroxiredoxins I–VI (Prxs) have recently been shown to have a role in the tumorigenesis of astrocytic brain tumours. In some tumour types they are associated with Nrf2 (transcription factor NF-E2-related factor), a sensor of oxidative stress, and DJ-1 (also known as PARK7), a protein known to stabilise Nrf2.MethodsWe investigated the ...
Kinnula Vuokko L. +8 more
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Fish Peroxiredoxins and Their Role in Immunity [PDF]
Biology, 2015 Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The most studied roles of Prx1 and Prx2 are immunological.
Yulema Valero +4 more
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The role of peroxiredoxins in cancer
Molecular and Clinical Oncology, 2017 Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite. They are highly involved in the control of various physiological functions, including cell growth, differentiation, apoptosis, embryonic development, lipid ...
NICOLUSSI, Arianna +4 more
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Synechococcus sp. PCC7002 Uses Peroxiredoxin to Cope with Reactive Sulfur Species Stress
mBio, 2022 Cyanobacteria are a widely distributed group of microorganisms in the ocean, and they often need to cope with the stress of reactive sulfur species, such as sulfide and sulfane sulfur.
Daixi Liu +10 more
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Molecules and Cells, 2016 Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012).
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Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper
Antioxidants, 2018 Cancer cells are abnormal cells that do not comply with tissue homeostasis but undergo uncontrolled proliferation. Such abnormality is driven mostly by somatic mutations on oncogenes and tumor suppressors.
Sang Won Kang +2 more
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Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family [PDF]
, 2019 The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities.
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