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Frontiers in Pharmacology, 2016 Neuroinflammation is known to have a pivotal role in the pathogenesis of Alzheimer's disease (AD), and curcumin has been reported to have therapeutical effects on AD because of its anti-inflammatory effects.
Yu Wang, Li Zhonghao, Cheng Xiao
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Peroxisome proliferator‐activated receptor gamma in human prostate carcinoma
Pathology International, 2009Peroxisome proliferator‐activated receptor (PPAR) is a member of the nuclear hormone receptor superfamily of transcription factors. Peroxisome proliferator‐activated receptor gamma (PPARγ) plays an important role in the regulation of lipid homeostasis, adipogenesis, insulin resistance, and development of various organs. Agonists of PPARγ have been also
Yasuhiro, Nakamura +4 more
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The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity
Current Diabetes Reports, 2002Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which upon activation with various natural and synthetic ligands, stimulates the transcription of genes responsible for growth and differentiation of adipocytes. Furthermore, PPAR gamma is the receptor for the insulin-sensitizing thiazolidinediones, which are commonly ...
Francesco S, Celi, Alan R, Shuldiner
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Peroxisome Proliferator–activated Receptor Gamma in the Colon
Journal of Clinical Gastroenterology, 2014Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, originally described in adipose tissue, which controls the expression of a large number of regulatory genes in lipid metabolism and insulin sensitization. Well known by endocrinologists, thiazolidinedionesare classical PPARγ synthetic agonists, which were currently used as ...
Silvia, Speca +2 more
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Peroxisome proliferator-activated receptor γ and atherosclerosis
Current Hypertension Reports, 2002Within the past couple of years, peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear transcription factor expressed in vascular cells, has received growing interest in vascular biology and atherosclerosis research. Initially, PPARgamma was identified as a regulator of gene expression in lipid metabolism and adipogenesis, but recent ...
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Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents
Drug News & Perspectives, 2010Peroxisome proliferator-activated receptor gamma (PPARgamma) has already been considered as an attractive therapeutic target for the treatment of metabolic disorders. Recently, PPARgamma agonists were shown to effectively attenuate oxidative stress, inflammation and apoptosis in the central nervous system.
Ravinder K, Kaundal, Shyam S, Sharma
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Peroxisome proliferator-activated receptor gamma: promising target in glioblastoma
Panminerva Medica, 2018Glioblastoma, also known as glioblastoma multiforme, is the most common and worldwide-spread cancer that begins within the brain. Glioblastomas represent 15% of brain tumors. The most common length of survival following diagnosis is 12 to 14 months with less than 3% to 5% of people surviving longer than five years.
Gaurav, Gupta +7 more
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FAM3A is a target gene of peroxisome proliferator-activated receptor gamma
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013To date, the biological function of FAM3A, the first member of FAM3 gene family, remains unknown. We aimed to investigate whether the expression of FAM3A in liver cells is regulated by peroxisome proliferator-activated receptors (PPARs).The transcriptional activity of human and mouse FAM3A gene promoters was determined by luciferase reporter assay ...
Yanlan, Zhou +8 more
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Peroxisome proliferator-activated receptor γ in malignant diseases
Critical Reviews in Oncology/Hematology, 2006Peroxisome proliferator-activated receptor gamma (PPAR-gamma) belongs to the family of nuclear hormone receptors (NHRs) and is a ligand-activated transcription factor. There are four mRNAs, PPAR-gamma1, PPAR-gamma2, PPAR-gamma3 and PPAR-gamma4, which encode two proteins, PPAR-gamma1and PPAR-gamma2. PPAR-gamma consists of five or six structural regions (
Tingting, Wang +4 more
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Oregano: A Source for Peroxisome Proliferator-Activated Receptor γ Antagonists
Journal of Agricultural and Food Chemistry, 2008Peroxisome proliferator-activated receptors (PPARs) are drug targets for several perturbations of metabolic syndrome, defined as the coexistence of obesity, hyperglycemia, hypertension, and hyper/dyslipidemia. In this study, PPAR activation by oregano (e.g., Origanum vulgare) and its components was tested. Oregano extracts bind but do not transactivate
MUELLER M +5 more
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