Results 191 to 200 of about 105,604 (235)
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Peroxisome proliferator-activated receptor-γ in the renal mesangium
Current Opinion in Nephrology and Hypertension, 2002The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that are expressed in a variety of tissues, including the liver (PPARalpha), adipose tissue, vascular smooth muscle, the heart, skeletal muscle, and the kidney (PPARgamma). PPARdelta is expressed ubiquitously.
Willa A, Hsueh, Susanne B, Nicholas
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Peroxisome proliferator-activated receptor γ in diabetes and metabolism
Trends in Pharmacological Sciences, 2004The peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been the focus of intense research during the past decade because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. Recent advances include the discovery of novel genes that are regulated by PPAR-gamma, which helps explain ...
Shamina M, Rangwala, Mitchell A, Lazar
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Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease
Annual Review of Biochemistry, 2001▪ Abstract The nuclear peroxisome proliferator–activated receptor γ (PPARγ) is a transcription factor that is activated by polyunsaturated fatty acids and their metabolites and is essential for fat cell formation. Although obesity is a strong risk factor for type 2 diabetes mellitus and other metabolic diseases, potent PPARγ activators such as the ...
T M, Willson, M H, Lambert, S A, Kliewer
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Eigenvalue Analysis of Peroxisome Proliferator-Activated Receptor γ Agonists
Journal of Chemical Information and Computer Sciences, 2003Eigenvalue analysis (EVA) was conducted on a series of potent agonists of peroxisome proliferator-activated receptor gamma (PPARgamma). Predictive EVA quantitative structure-activity relationship (QSAR) models were established using the SYBYL package, which had conventional r2 and cross-validated coefficient (q2) values up to 0.920 and 0.587 for the ...
Chenzhong Liao +4 more
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Peroxisome proliferator-activated receptor gamma and cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2003The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have anticancer activity against a wide variety of neoplastic cells in vitro. Animal studies have chronicled their in vivo anticancer effects and chemopreventive capabilities.
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Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis.
Archivum immunologiae et therapiae experimentalis, 2007This review describes the role of the nuclear hormone receptor PPARgamma as a double-edged sword in sepsis. On the one hand, PPARgamma inhibits pro-inflammatory gene expression, predominantly by scavenging transcription factors and their cofactors, thus preventing them from binding to their cognate binding sites in the promoters of target genes.
Andreas, von Knethen +2 more
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