Results 51 to 60 of about 105,604 (235)

Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy

Journal of Diabetes Investigation, 2020
Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine.
Yung‐Nien Chen, Pei‐Wen Wang, Shih‐Chen Tung, Ming‐Chun Kuo, Shao‐Wen Weng, Chen‐Kai Chou, Chih‐Min Chang, Chia‐Jen Tsa, Cheng‐Feng Taso, Feng‐Chih Shen, Jung‐Fu Chen   +10 more
doaj   +1 more source

Peroxisome proliferator-activated receptor gamma as modulator of inflammation in pulmonary sarcoidosis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2013
Peroxisome proliferator-activated receptor (PPAR) includes the family of ligand-activated transcription factors which belong to the group of nuclear hormone receptors and are connected to retinoid, glucocorticoid and thyroid hormone receptors.
Pejčić Tatjana, Stanković Ivana, Rađenović-Petković Tatjana, Nastasijević-Borovac Desa, Đorđević Ivanka, Jeftović-Stoimenov Tatjana   +5 more
doaj   +1 more source

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Biochemical Pharmacology, 2014
Graphical ...
Limei Wang, B. Waltenberger, E. Pferschy-Wenzig, M. Blunder, Xin Liu, Clemens Malainer, Tina Blažević, S. Schwaiger, J. Rollinger, E. Heiss, D. Schuster, B. Kopp, R. Bauer, H. Stuppner, V. Dirsch, A. Atanasov   +15 more
semanticscholar   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Reduction in Obesity-Related Hepatic Fibrosis by SR1664

Biology, 2023
Peroxisome-proliferator-activated receptor gamma (PPARγ) is a transcription factor with adipogenic, insulin-sensitizing, and antifibrotic properties.
Benita L. McVicker, Ronda L. Simpson, Frederick G. Hamel, Robert G. Bennett   +3 more
doaj   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Life Style-Related Diseases of the Digestive System: Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment

Journal of Pharmacological Sciences, 2007
Life style-related diseases are associated with an increased risk of colorectal cancer (CRC). Recently, an association has been demonstrated between obesity and CRC.
Hirokazu Takahashi, Kyoko Yoneda, Ayako Tomimoto, Hiroki Endo, Toshio Fujisawa, Hiroshi Iida, Hironori Mawatari, Yuichi Nozaki, Tamon Ikeda, Tomoyuki Akiyama, Masato Yoneda, Masahiko Inamori, Yasunobu Abe, Satoru Saito, Atsushi Nakajima, Hitoshi Nakagama   +15 more
doaj   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source