Results 41 to 50 of about 105,604 (235)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation

Journal of Lipid Research, 2023
White adipose tissue regulation is key to metabolic health, yet still perplexing. The chief endocannabinoid anandamide metabolite, prostaglandin F2α ethanolamide (PGF2αEA), inhibits adipogenesis, that is, the formation of mature adipocytes.
Besma Boubertakh, Olivier Courtemanche, David Marsolais, Vincenzo Di Marzo, Cristoforo Silvestri   +4 more
doaj   +1 more source

Evolution of peroxisome proliferator-activated receptor gamma alternative splicing

Frontiers in Bioscience, 2010
Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays an important role in the control of energy balance and lipid and glucose homeostasis. Different transcript variants were investigated not only in human but also in other vertebrates.
Tonghai, Dou, Jiaxi, Xu, Yuan, Gao, Jianlei, Gu, Chaoneng, Ji, Yi, Xie, Yan, Zhou   +6 more
openaire   +2 more sources

Denatonium Benzoate, the Most Bitter Compound, Reduces Weight by Promoting Adipocyte Browning

Metabolites
Objectives: Obesity remains a global health challenge, and promoting white adipose tissue browning has emerged as a promising anti-obesity strategy. This study aimed to investigate the anti-obesity effects of denatonium benzoate (DB) and elucidate its ...
Yiqin Niu, Junhui Shao, Yanping Teng, Ce Zhang, Xin Xie, Shimeng Guo   +5 more
doaj   +1 more source

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Nature Communications, 2018
Peroxisome proliferator-activated receptor gamma (PPARγ) is a target for insulin sensitizing drugs. Here the authors combine NMR, X-ray crystallography and MD simulations and report a structural mechanism for eliciting PPARγ inverse agonism, where ...
Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A. Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Anne-Laure Blayo, Patrick R. Griffin, Theodore M. Kamenecka, Travis S. Hughes, Douglas J. Kojetin   +13 more
doaj   +1 more source

Peroxisome proliferator‐activated receptor γ: the more the merrier? [PDF]

European Journal of Clinical Investigation, 2005
AbstractThe consequence of activating the nuclear hormone receptor, peroxisome proliferator‐activated receptor gamma (PPARγ), which coordinates adipocyte differentiation, validates the concept, ‘you are what you eat’. Excessive caloric intake leads to fat formation if the energy from these nutrients is not expended.
Argmann, Carmen, Cock, T.-A., Auwerx, Johan   +2 more
openaire   +3 more sources

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Clinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiency[S]

Journal of Lipid Research, 2012
Familial partial lipodystrophy (FPLD) is characterized by abnormal fat distribution and a metabolic syndrome with hypertriglyceridemia. We identified a family with a severe form of FPLD3 with never-reported clinical features and a novel mutation ...
Philippe M. Campeau, Olga Astapova, Rebecca Martins, Jean Bergeron, Patrick Couture, Robert A. Hegele, Todd Leff, Claude Gagné   +7 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source