Results 31 to 40 of about 105,604 (235)
Peroxisome proliferator-activated receptor gamma agonists in renal disease [PDF]
European Journal of Endocrinology, 2006 Type 2 diabetes is a well recognised cause of chronic renal failure (CRF). Only few oral antidiabetic drugs can be used for treating type 2 diabetes in patients with CRF. Among them are repaglinide, a rapid-acting prandial insulin releaser, and peroxisome proliferator-activated receptor gamma (PPARγ) agonists, such as rosiglitazone and pioglitazone ...
Pedro, Iglesias, Juan J, Díez
openaire +2 more sources
Relaxin signaling activates peroxisome proliferator-activated receptor gamma [PDF]
Molecular and Cellular Endocrinology, 2010 Relaxin is a polypeptide hormone that triggers multiple signaling pathways through its receptor RXFP1 (relaxin family peptide receptor 1). Many of relaxin's functions, including vascular and antifibrotic effects, are similar to those induced by activation of PPARgamma.
Singh, Sudhir, Bennett, Robert G.
openaire +2 more sources
Seminars in Nephrology, 2018 Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a key transcriptional regulator of mitochondrial biogenesis and function. Several recent studies evaluated the role of PGC-1α in various renal cell types in healthy and disease ...
Szu-Han Li, K. Suszták
semanticscholar +1 more source
Medicine Science, 2019 The Peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the nuclear receptor family of transcription factors. In addition to its role in lipid and glucose metabolisms, PPARγ has possible roles in tumor suppression.
Hatice Kurnaz +3 more
doaj +1 more source
Expression of Peroxisome Proliferator Activated Receptor gamma in Prostatic Adenocarcinoma
Journal of Korean Medical Science, 2015 Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-γ ligands are anti-tumorigenic in prostate cancer due to anti-proliferative and pro-differentiation effects.
Hyung Kyu Park +8 more
openaire +2 more sources
Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity
Diabetes, Metabolic Syndrome and Obesity, 2020 Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye
Ayza MA +4 more
doaj
Scientific Reports, 2017 Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that is deregulated in obesity. PPARγ exerts diverse antineoplastic effects.
T. K. Motawi +3 more
semanticscholar +1 more source
The Turkish Journal of GastroenterologyBackground/Aims: Hepatic ischemia-reperfusion injury (HIRI) refers to the damage caused by metabolic imbalance post-ischemia upon reperfusion, often occurring in scenarios like hemorrhagic shock, liver resection, and liver transplantation.
Xinyu Liu +4 more
doaj +1 more source
Frontiers in Genetics, 2019 The nuclear receptors known as peroxisome proliferator activated receptor gamma (PPARG) are lipid-activated transcription factors that have emerged as key regulators of inflammation. PPARG ligands have been shown to have an anti-proliferative effect on a
Simran Kaur +4 more
doaj +1 more source
A molecular switch regulating transcriptional repression and activation of PPARγ
Nature Communications, 2020 Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism.
Jinsai Shang +8 more
doaj +1 more source