Results 21 to 30 of about 105,604 (235)
Roles of Peroxisome Proliferator-Activated Receptor-gamma on brain and peripheral inflammation
Cellular and molecular neurobiology, 2017 Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the pathology of numerous diseases involving diabetes, stroke, cancer, or obesity.
S. Villapol
semanticscholar +1 more source
CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
Cell Reports, 2021 Summary: Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic AMP-regulated transcriptional coactivator 1 (CRTC1) and mastermind-like 2 (MAML2). The
Adele M. Musicant +16 more
doaj +1 more source
Journal of Diabetes Investigation, 2019 Aims/Introduction Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive ...
Qihong Zhao +9 more
doaj +1 more source
Frontiers in Immunology, 2018 Inflammation and oxidative stress are common and co-substantial pathological processes accompanying, promoting, and even initiating numerous cancers.
Alexandre Vallée, Y. Lecarpentier
semanticscholar +1 more source
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis [PDF]
Journal of Molecular Endocrinology, 2001 Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization.
Fajas, L, Debril, Mb, Auwerx, J
openaire +3 more sources
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors [PDF]
Endocrinology and Metabolism, 2022 Background Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Yong-Jik Lee +8 more
doaj +1 more source
Defining a conformational ensemble that directs activation of PPARγ
Nature Communications, 2018 Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conformational
Ian M. Chrisman +15 more
doaj +1 more source
Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders
Clinical Medicine Insights: Oncology, 2015 Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a class of nuclear hormone receptors intimately involved in the regulation of expression of myriad genes that regulate energy metabolism, cell differentiation, apoptosis, and ...
Ping Ren +4 more
doaj +2 more sources
A Standardized Seed Extract Regulates Browning of White Adipose Tissue in High-Fat Diet Model Mice
Natural Product Communications, 2021 Thermogenesis-mediated energy expenditure is a promising strategy to combat obesity. Aframomum melegueta commonly known as grains of paradise (GP) is a popular spice with medicinal attributes in promoting health.
Heggar Venkataramana Sudeep +5 more
doaj +1 more source
Protein markers of mitochondria formation and alteration in patients with impaired blood circulation
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015 Patients with abnormal left ventricular outflow tract had middle lactic acidemia with detected cytochrome C release into the bloodstream and liberation of protein PGC1a (peroxisome proliferator-activated receptor gamma coactivator-1alpha) with elevation ...
E S. Alekseevskaya +7 more
doaj +1 more source