Results 11 to 20 of about 105,604 (235)

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in hepatocellular carcinoma

Tumor Biology, 2017
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha plays a crucial role in regulating the biosynthesis of mitochondria, which is closely linked to the energy metabolism in various tumors.
Rui Liu, Haiyang Zhang, Yan Zhang, Shuang Li, Xinyi Wang, Xia Wang, Cheng Wang, Bin Liu, Ke Zen, Chen-yu Zhang, Chunni Zhang, Yi Ba   +11 more
doaj   +2 more sources

Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase

Cell Reports, 2018
Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved.
David Lasar, Matthias Rosenwald, Elke Kiehlmann, Miroslav Balaz, Bettina Tall, Lennart Opitz, Martin E. Lidell, Nicola Zamboni, Petra Krznar, Wenfei Sun, Lukas Varga, Patrik Stefanicka, Jozef Ukropec, Pirjo Nuutila, Kirsi Virtanen, Ez-Zoubir Amri, Sven Enerbäck, Walter Wahli, Christian Wolfrum   +18 more
doaj   +2 more sources

Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

Asian Journal of Andrology, 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily.
Li-Li Liu, Hua Xian, Jing-Chen Cao, Chong Zhang, Yong-Hui Zhang, Miao-Miao Chen, Yi Qian, Ming Jiang   +7 more
doaj   +2 more sources

Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma [PDF]

Trends in Pharmacological Sciences, 2015
Nuclear receptors are ligand-activated transcription factors, which represent a primary class of drug targets. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a key player in various biological processes. PPARγ is widely known as the target protein of the thiazolidinediones for treating type 2 diabetes.
Sascha Sauer
openaire   +4 more sources

In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays.

Toxicology and Applied Pharmacology, 2022
Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, additional work is needed to characterize PFAS activity on PPAR gamma (PPARγ) and other nuclear receptors. We
Nicola Evans, Justin M. Conley, M. Cardon, P. Hartig, Elizabeth K. Medlock-Kakaley, L. Earl Gray   +5 more
semanticscholar   +1 more source

Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma

ACS Omega, 2021
Peroxisome proliferator receptor gamma (PPARγ), a type II nuclear receptor, fundamental in the regulation of genes, glucose metabolism, and insulin sensitization has been shown to be impacted by per- and poly-fluoroalkyl substances (PFASs).
Nuno M. S. Almeida, Yiğitcan Eken, A. Wilson   +2 more
semanticscholar   +1 more source

Peroxisome proliferator-activated receptor gamma in white and brown adipocyte regulation and differentiation.

Physiological Research, 2020
In as early as 1997, the World Health Organization officially recognized obesity as a chronic disease. The current epidemic of obesity and overweightness has aroused great interest in the study of adipose tissue formation.
Hui Wu, Xiaohua Li, Chunyan Shen
semanticscholar   +1 more source

Peroxisome Proliferator-Activated Receptor .GAMMA. and Cardiovascular Diseases

Circulation Journal, 2009
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily and form heterodimers with retinoid X receptor. Three PPAR isoforms have been isolated and termed alpha, beta (or delta) and gamma. Although PPARgamma is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose ...
Takano, Hiroyuki, Komuro, Issei
openaire   +3 more sources

Vitamin D3 supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B

Journal of Diabetes Investigation, 2019
Aims/Introduction Vitamin D3 deficiency can lead to male hypogonadism in diabetes mellitus, but the target organs and the mechanism driving the disorder are unclear. This experiment was designed to study the relationship between vitamin D3 deficiency and
Yang Liu, Yanyan He, Qingzhu Wang, Feng Guo, Fengjuan Huang, Linlin Ji, Tingting An, Guijun Qin   +7 more
doaj   +1 more source

Intestinal absorption of astaxanthin and fucoxanthin: Role peroxisome proliferator-activated receptor gamma and scavenger receptor B1 and modulation by selected peroxisome proliferator-activated receptor gamma ligands

National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Non-provitamin A carotenoids astaxanthin (AX) and fucoxanthin (FX) are bioactive molecules that are abundant in seafood. Although their dietary intake is beneficial, only around 10% of ingested carotenoids are absorbed.
Raghunandan Purohith, Baskaran Vallikannan, Priya Shubha Babu, Nanjunda Swamy Shivananju   +3 more
doaj   +1 more source