Results 61 to 70 of about 53,252 (304)

Peroxisomal Disorders

Neurologic Clinics, 1990
Although peroxisomes were once considered a vestige, their importance in cellular metabolism is clearly established by the many inherited diseases that have been described in the past two decades. Unfortunately there is no definitive treatment for the various disorders, but based on the recognition of the biochemical abnormalities, prenatal testing and
S, Naidu, H W, Moser
openaire   +3 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Peroxisome deficient invertebrate and vertebrate animal models

Frontiers in Physiology, 2013
Although peroxisomes are ubiquitous organelles in all animal species, their importance for the functioning of tissues and organs remains largely unresolved.
Paul P. Van Veldhoven, Myriam eBaes
doaj   +1 more source

Sharing the wealth: The versatility of proteins targeted to peroxisomes and other organelles

Frontiers in Cell and Developmental Biology, 2022
Peroxisomes are eukaryotic organelles with critical functions in cellular energy and lipid metabolism. Depending on the organism, cell type, and developmental stage, they are involved in numerous other metabolic and regulatory pathways.
Elena Bittner, Thorsten Stehlik, Johannes Freitag   +2 more
doaj   +1 more source

Pmp27 Promotes Peroxisomal Proliferation [PDF]

, 1995
Peroxisomes perform many essential functions in eukaryotic cells. The weight of evidence indicates that these organelles divide by budding from preexisting peroxisomes. This process is not understood at the molecular level.
Dyer, John M.,, Goodman, Joel M.,, Krimkevich, Yelena I.,, Lark, Richard H.,, Marshall, Pamela A.,, Veenhuis, Marten,   +5 more
core   +5 more sources

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Plant peroxisomes: A nitro-oxidative cocktail

Redox Biology, 2017
Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability.
Francisco J. Corpas, Juan B. Barroso, José M. Palma, Marta Rodriguez-Ruiz   +3 more
doaj   +1 more source

Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Frontiers in Cellular Neuroscience, 2020
Peroxisomes exist in most cells, where they participate in lipid metabolism, as well as scavenging the reactive oxygen species (ROS) that are produced as by-products of their metabolic functions.
Ndidi-Ese Uzor, Ndidi-Ese Uzor, Louise D. McCullough, Louise D. McCullough, Louise D. McCullough, Andrey S. Tsvetkov, Andrey S. Tsvetkov, Andrey S. Tsvetkov   +7 more
doaj   +1 more source

Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics

, 2020
Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics.
Platzman, I., Schröter, M., Spatz, J., Staufer, O.   +3 more
core   +1 more source

Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis [PDF]

, 2015
A recent model for peroxisome biogenesis postulates that peroxisomes form de novo continuously in wild-type cells by heterotypic fusion of endoplasmic reticulum–derived vesicles containing distinct sets of peroxisomal membrane proteins.
Agne, Agrawal, Alison M. Motley, Aranovich, Arimura, Barton, Bascom, Bonekamp, Cepińska, Chen, David, Debelyy, Delille, Dimitrov, Elgersma, Ewald H. Hettema, Faber, Fakieh, Fang, Ghaemmaghami, Gietz, Goldstein, Gould, Gould, Gärtner, Haan, Halbach, Hensel, Hettema, Hettema, Hoepfner, Hoepfner, Huybrechts, James M. Nuttall, Jones, Karnik, Kiel, Kim, Kim, Knoblach, Knoops, Koek, Kragt, Kuravi, Lakhan Ekal, Lam, Lazarow, Liu, Liu, Managadze, Manivannan, Matsuzaki, Mattiazzi Ušaj, Menendez-Benito, Miyata, Miyata, Motley, Motley, Motley, Motley, Mukherji, Nagotu, Nishimura, Nunnari, Nuttall, Nuttall, Okumoto, Otera, Paul C. Galvin, Pinto, Platta, Platta, Platta, Platta, Pu, Rosenkranz, Rottensteiner, Sacksteder, Santos, Tabak, Tam, Titorenko, Titorenko, Toro, Uetz, van der Zand, van der Zand, van der Zand, van Roermund, Vizeacoumar, Williams, Williams, Yagita, Yan   +93 more
core   +2 more sources